Tbio MMP20 Matrix metalloproteinase-20

Protein Summary

Description

Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O60882
• Q6DKT9
• MMP-20

Gene Name

• MMP20

Ensembl ID

• ENST00000260228
• ENSP00000260228
• ENSG00000137674

Symbol

• AI2A2
• MMP-20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
cell line	0.61
gene perturbation	0.6
molecular function	0.56
kinase perturbation	0.54

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Matrix Metalloproteinase-20

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Matrix Metalloproteinase-20

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.65   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 263   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.65   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 263   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0