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Tbio
SH2D1A
SH2 domain-containing protein 1A

Protein Summary
Description
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360027
  • ENSP00000353126
  • ENSG00000183918
  • ENST00000371139
  • ENSP00000360181
  • ENST00000477673
  • ENSP00000477094

Symbol
  • DSHP
  • SAP
  • LYP
  • SAP
  • XLP
  • DSHP
  • EBVS
  • IMD5
  • XLPD
  • MTCP1
  • XLPD1
  • SAP/SH2D1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
biological term
0.72
PubMedID
0.7
gene perturbation
0.68
cell type or tissue
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.92   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 510.92   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (100)
1 – 10 of 100
FYN
Tclin
Family: Kinase
Novelty: 0.00092113
Score: 0.997
Data Source: STRINGDB
SLAMF1
Tbio
Novelty: 0.00121506
Score: 0.986
Data Source: STRINGDB
SLAMF6
Tbio
Novelty: 0.01594793
Score: 0.982
Data Source: Reactome,STRINGDB
CD244
Tbio
Novelty: 0.00484738
Score: 0.967
Data Source: STRINGDB
LY9
Tbio
Novelty: 0.02543757
Score: 0.881
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00009742
Score: 0.844
Data Source: STRINGDB
FRK
Tchem
Family: Kinase
Novelty: 0.01371938
Score: 0.813
Data Source: STRINGDB
SLAMF7
Tclin
Novelty: 0.01669532
Score: 0.813
Data Source: STRINGDB
CD84
Tbio
Novelty: 0.03590853
Score: 0.809
Data Source: STRINGDB
YES1
Tclin
Family: Kinase
Novelty: 0.006917
Score: 0.782
Data Source: STRINGDB
Publication Statistics
PubMed Score  510.92

PubMed score by year
PubTator Score  536.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer