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Tbio
SH2D1A
SH2 domain-containing protein 1A

Protein Summary
Description
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360027
  • ENSP00000353126
  • ENSG00000183918
  • ENST00000371139
  • ENSP00000360181
  • ENST00000477673
  • ENSP00000477094

Symbol
  • DSHP
  • SAP
  • LYP
  • SAP
  • XLP
  • DSHP
  • EBVS
  • IMD5
  • XLPD
  • MTCP1
  • XLPD1
  • SAP/SH2D1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
biological term
0.72
PubMedID
0.7
gene perturbation
0.68
cell type or tissue
0.52


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.06   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 218.06   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0