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Tbio
SH2D1A
SH2 domain-containing protein 1A

Protein Summary
Description
Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2 (PubMed:11806999). However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1 (PubMed:12458214). Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells (By similarity). May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360027
  • ENSP00000353126
  • ENSG00000183918
  • ENST00000371139
  • ENSP00000360181
  • ENST00000477673
  • ENSP00000477094

Symbol
  • DSHP
  • SAP
  • LYP
  • SAP
  • XLP
  • DSHP
  • EBVS
  • IMD5
  • XLPD
  • MTCP1
  • XLPD1
  • SAP/SH2D1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.74
biological term
0.72
PubMedID
0.7
gene perturbation
0.68
cell type or tissue
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.47   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 164.47   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 1A
VGNC:13462
740507
Macaque
SH2 domain containing 1A
574156
Mouse
MGI:1328352
20400
Rat
RGD:1562408
501502
Dog
SH2 domain containing 1A
VGNC:54598
612899
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2 domain containing 1A
Macaque
SH2 domain containing 1A
Mouse
Rat
Dog
SH2 domain containing 1A
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60880-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (100)
1 – 10 of 100
FYN
Tclin
Family: Kinase
Novelty: 0.00072167
Score: 0.997
Data Source: STRINGDB
SLAMF1
Tbio
Novelty: 0.00112892
Score: 0.986
Data Source: STRINGDB
SLAMF6
Tbio
Novelty: 0.01459284
Score: 0.982
Data Source: Reactome,STRINGDB
CD244
Tbio
Novelty: 0.01137579
Score: 0.967
Data Source: STRINGDB
LY9
Tbio
Novelty: 0.01892831
Score: 0.881
Data Source: STRINGDB
SRC
Tclin
Family: Kinase
Novelty: 0.00008479
Score: 0.844
Data Source: STRINGDB
FRK
Tchem
Family: Kinase
Novelty: 0.00715757
Score: 0.813
Data Source: STRINGDB
SLAMF7
Tclin
Novelty: 0.01014396
Score: 0.813
Data Source: STRINGDB
CD84
Tbio
Novelty: 0.02811289
Score: 0.809
Data Source: STRINGDB
YES1
Tclin
Family: Kinase
Novelty: 0.00534936
Score: 0.782
Data Source: STRINGDB
Publication Statistics
PubMed Score  164.47

PubMed score by year
PubTator Score  536.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer