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Tbio
DIAPH2
Protein diaphanous homolog 2

Protein Summary
Description
Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transduction pathway, in which isoform 3 and CSK are sequentially activated by RHOD to regulate the motility of early endosomes through interactions with the actin cytoskeleton. The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324765
  • ENSP00000321348
  • ENSG00000147202
  • ENST00000373049
  • ENSP00000362140

Symbol
  • DIA
  • DIA
  • POF
  • DIA2
  • DRF2
  • POF2
  • POF2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell type or tissue
0.65
cell line
0.54
microRNA
0.54
tissue sample
0.54


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.67   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.67   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diaphanous related formin 2
VGNC:2727
473694
Macaque
diaphanous related formin 2
699140
Mouse
MGI:1858500
54004
Dog
diaphanous related formin 2
VGNC:39956
480977
Horse
diaphanous related formin 2
VGNC:17184
100057058
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diaphanous related formin 2
Macaque
diaphanous related formin 2
Mouse
Dog
diaphanous related formin 2
Horse
diaphanous related formin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60879-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate Formins
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases Activate Formins
Signal Transduction
Signaling by Rho GTPases
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (65)
1 – 10 of 65
SOWAHB
Tdark
Novelty:  1.09724527
p_int:  0.999998714
p_ni:  0.000001072
p_wrong:  2.14e-7
Data Source:  BioPlex
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.931
Data Source:  STRINGDB
PFN2
Tbio
Novelty:  0.00605366
Score:  0.864
Data Source:  STRINGDB
PFN1
Tbio
Novelty:  0.0048861
Score:  0.863
Data Source:  STRINGDB
PFN4
Tdark
Novelty:  0.2502443
Score:  0.859
Data Source:  STRINGDB
PFN3
Tdark
Novelty:  0.11291078
Score:  0.81
Data Source:  STRINGDB
DIAPH1
Tbio
Novelty:  0.0150259
Score:  0.807
Data Source:  STRINGDB
DIAPH3
Tbio
Novelty:  0.01165283
Score:  0.805
Data Source:  STRINGDB
RHOD
Tbio
Family:  Enzyme
Novelty:  0.0029764
Score:  0.765
Data Source:  Reactome,STRINGDB
POF1B
Tbio
Novelty:  0.1232792
Score:  0.726
Data Source:  STRINGDB
Publication Statistics
PubMed Score  49.67

PubMed score by year
PubTator Score  57.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer