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Tbio
KIN
DNA/RNA-binding protein KIN17

Protein Summary
Description
Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteris ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379562
  • ENSP00000368881
  • ENSG00000151657

Symbol
  • BTCD
  • KIN17
  • BTCD
  • Rts2
  • KIN17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
histone modification site profile
0.77
kinase perturbation
0.71
hub protein
0.63
transcription factor binding site profile
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.87   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.87   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
1
2
2
95.9
red blood cell density measurement
1
1
1
42.3
mean reticulocyte volume
1
1
1
38.8
late-onset Alzheimers disease
1
1
0
6.1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pentraxin-related protein PTX3 measurement
2
95.9
red blood cell density measurement
1
42.3
mean reticulocyte volume
1
38.8
late-onset Alzheimers disease
0
6.1
38.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Kin17 DNA and RNA binding protein
VGNC:7237
450293
Macaque
Kin17 DNA and RNA binding protein
713634
Mouse
MGI:96676
16588
Rat
RGD:1596107
689197
Dog
Kin17 DNA and RNA binding protein
VGNC:42417
478010
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Kin17 DNA and RNA binding protein
Macaque
Kin17 DNA and RNA binding protein
Mouse
Rat
Dog
Kin17 DNA and RNA binding protein
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60870-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein methylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Protein methylation
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (67)
1 – 10 of 67
METTL22
Tdark
Family:  Enzyme
Novelty:  0.83516873
p_int:  1
Score:  0.993
Data Source:  BioPlex,Reactome,STRINGDB
RECQL5
Tbio
Family:  Enzyme
Novelty:  0.01558497
Score:  0.899
Data Source:  STRINGDB
EIF2D
Tbio
Novelty:  0.03765592
Score:  0.869
Data Source:  STRINGDB
METTL18
Tdark
Family:  Enzyme
Novelty:  0.3377377
Score:  0.792
Data Source:  STRINGDB
KIRREL1
Tbio
Novelty:  0.03216031
Score:  0.755
Data Source:  STRINGDB
METTL21A
Tbio
Family:  Enzyme
Novelty:  0.31897774
Score:  0.74
Data Source:  STRINGDB
VCPKMT
Tbio
Family:  Enzyme
Novelty:  0.37849297
Score:  0.735
Data Source:  STRINGDB
ETFBKMT
Tbio
Family:  Enzyme
Novelty:  0.33247149
Score:  0.672
Data Source:  STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.643
Data Source:  STRINGDB
EEF2KMT
Tdark
Family:  Enzyme
Novelty:  0.33892681
Score:  0.631
Data Source:  STRINGDB
Publication Statistics
PubMed Score  84.87

PubMed score by year
PubTator Score  370.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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