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Tbio
EDF1
Endothelial differentiation-related factor 1

Protein Summary
Description
Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. This gene encodes a protein that may regulate endothelial cell differentiation, lipid metabolism, and hormone-induced cardiomyocyte hypertrophy. The encoded protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224073
  • ENSP00000224073
  • ENSG00000107223
  • ENST00000371648
  • ENSP00000360711
  • ENST00000371649
  • ENSP00000360712

Symbol
  • MBF1
  • EDF-1
  • CFAP280
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.93
molecular function
0.9
gene perturbation
0.85
histone modification site profile
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.07   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.07   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (81)
STIP1
Tbio
Novelty:  0.00590952
Score:  0.898
Data Source:  STRINGDB
PTGES3
Tbio
Family:  Enzyme
Novelty:  0.0082783
Score:  0.836
Data Source:  STRINGDB
TBP
Tbio
Novelty:  0.00034941
Score:  0.805
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.767
Data Source:  STRINGDB
DNAJB1
Tbio
Novelty:  0.00139956
Score:  0.753
Data Source:  STRINGDB
HSP90AB1
Tchem
Novelty:  0.00907961
Score:  0.747
Data Source:  STRINGDB
NR5A1
Tchem
Family:  NR
Novelty:  0.00126037
Score:  0.73
Data Source:  STRINGDB
NSFL1C
Tbio
Novelty:  0.05494848
Score:  0.728
Data Source:  STRINGDB
AHSA1
Tbio
Family:  Enzyme
Novelty:  0.01080001
Score:  0.724
Data Source:  STRINGDB
RPS23
Tbio
Novelty:  0.01846154
Score:  0.723
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
3
2
0
2.9
69.8
platelet crit
1
1
1
47.7
heel bone mineral density
1
1
1
28.1
corneal topography
1
1
1
12.2
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
2.9
69.8
platelet crit
1
47.7
heel bone mineral density
1
28.1
corneal topography
1
12.2
1
11.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endothelial differentiation related factor 1
VGNC:8818
748763
Macaque
endothelial differentiation related factor 1
708611
Mouse
MGI:1891227
59022
Rat
RGD:1308073
296570
Dog
endothelial differentiation related factor 1
VGNC:40197
480674
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endothelial differentiation related factor 1
Macaque
endothelial differentiation related factor 1
Mouse
Rat
Dog
endothelial differentiation related factor 1
Publication Statistics
PubMed Score 107.07
PubMed score by year
PubTator Score 28.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title