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Tbio
GAS7
Growth arrest-specific protein 7

Protein Summary
Description
May play a role in promoting maturation and morphological differentiation of cerebellar neurons. Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323816
  • ENSP00000322608
  • ENSG00000007237
  • ENST00000432992
  • ENSP00000407552
  • ENST00000437099
  • ENSP00000410108
  • ENST00000542249
  • ENSP00000443265
  • ENST00000579158
  • ENSP00000463527
  • ENST00000580865
  • ENSP00000463873
  • ENST00000585266
  • ENSP00000464240

Symbol
  • KIAA0394
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
kinase perturbation
0.76
gene perturbation
0.75
PubMedID
0.71
tissue sample
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.76   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 386   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.76   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 386   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
9
6
17
99.8
3
1
0
1.2
88.8
3
1
0
1.2
88.4
heel bone mineral density
2
1
2
77
Antiglaucoma preparations and miotics use measurement
1
1
1
56
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
17
99.8
0
1.2
88.8
0
1.2
88.4
heel bone mineral density
2
77
Antiglaucoma preparations and miotics use measurement
1
56
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (94)
1 – 10 of 94
NCKIPSD
Tbio
Novelty: 0.07453111
p_int: 0.9999988
p_wrong: 0.000001199
Score: 0.427
Data Source: BioPlex,STRINGDB
MLLT3
Tbio
Novelty: 0.00361056
Score: 0.777
Data Source: STRINGDB
WAS
Tbio
Novelty: 0.00087362
Score: 0.727
Data Source: STRINGDB
TMCO1
Tbio
Novelty: 0.04473381
Score: 0.679
Data Source: STRINGDB
SMARCB1
Tbio
Novelty: 0.00116387
Score: 0.663
Data Source: STRINGDB
RECQL4
Tbio
Family: Enzyme
Novelty: 0.00576141
Score: 0.655
Data Source: STRINGDB
ELL
Tbio
Family: Enzyme
Novelty: 0.00424352
Score: 0.648
Data Source: STRINGDB
LACTB
Tbio
Family: Enzyme
Novelty: 0.02200752
Score: 0.62
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.618
Data Source: STRINGDB
FMN1
Tbio
Novelty: 0.00130542
Score: 0.617
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.76

PubMed score by year
PubTator Score  14.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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