Tbio ZG16 Zymogen granule membrane protein 16

Protein Summary

Description

May play a role in protein trafficking. May act as a linker molecule between the submembranous matrix on the luminal side of zymogen granule membrane (ZGM) and aggregated secretory proteins during granule formation in the TGN.

Uniprot Accession IDs

• O60844
• B2R4Z3
• B9EK72
• Zymogen granule protein 16

Gene Name

• ZG16

Ensembl ID

• ENST00000400752
• ENSP00000383563
• ENSG00000174992

Symbol

• JCLN
• JCLN1
• ZG16A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.63
cellular component	0.6
gene perturbation	0.57
cell line	0.49
tissue	0.45

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.78   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 84   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.78   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0