Tchem EIF5B Eukaryotic translation initiation factor 5B

Protein Summary

Description

Plays a role in translation initiation. Translational GTPase that catalyzes the joining of the 40S and 60S subunits to form the 80S initiation complex with the initiator methionine-tRNA in the P-site base paired to the start codon. GTP binding and hydrolysis induces conformational changes in the enzyme that renders it active for productive interactions with the ribosome. The release of the enzyme after formation of the initiation complex is a prerequisite to form elongation-competent ribosomes. Accurate initiation of translation in eukaryotes is complex and requires many factors, some of which are composed of multiple subunits. The process is simpler in prokaryotes which have only three initiation factors (IF1, IF2, IF3). Two of these factors are conserved in eukaryotes: the homolog of IF1 is eIF1A and the homolog of IF2 is eIF5B. This gene encodes eIF5B. Factors eIF1A and eIF5B interact on the ribosome along with other initiation factors and GTP to position the initiation methionine tRNA on the start codon of the mRNA so that translation initiates accurately. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60841
• O95805
• Q53RV7
• Q53SI8
• Q9UF81
• Q9UMN7
• eIF-5B

Gene Name

• EIF5B

Ensembl ID

• ENST00000289371
• ENSP00000289371
• ENSG00000158417

Symbol

• IF2
• KIAA0741
• IF2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	0.99
transcription factor perturbation	0.97
disease perturbation	0.96
kinase perturbation	0.96
molecular function	0.96

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Initiation Factor / Eukaryotic Translation Initiation Factor 5b

Protein / Nucleic Acid Binding / Rna Binding Protein / Translation Factor / Translation Elongation Factor / Eukaryotic Translation Initiation Factor 5b

Protein / Hydrolase / Eukaryotic Translation Initiation Factor 5b

Protein / Enzyme Modulator / G-protein / Eukaryotic Translation Initiation Factor 5b

DTO Classes

Protein / Enzyme / Hydrolase / Eukaryotic Translation Initiation Factor 5b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 961.02   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 961.02   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0