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Tdark
TIMM17B
Mitochondrial import inner membrane translocase subunit Tim17-B

Protein Summary
Description
Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376582
  • ENSP00000365766
  • ENSG00000126768
  • ENST00000396779
  • ENSP00000379999
  • ENST00000465150
  • ENSP00000477073

Symbol
  • TIM17B
  • JM3
  • TIM17B
  • DXS9822
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
histone modification site profile
0.9
virus perturbation
0.79
cell type or tissue
0.78
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.53   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.53   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (104)
1 – 10 of 104
TIMM23
Tbio
Family:  Enzyme
Novelty:  0.06463808
Score:  0.999
Data Source:  STRINGDB
TIMM23B
Tdark
Family:  Enzyme
Novelty:  0.20164487
Score:  0.997
Data Source:  STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
Score:  0.994
Data Source:  STRINGDB
PAM16
Tbio
Family:  Enzyme
Novelty:  0.04932685
Score:  0.984
Data Source:  STRINGDB
TIMM44
Tbio
Family:  Enzyme
Novelty:  0.020862
Score:  0.977
Data Source:  STRINGDB
DNAJC19
Tbio
Family:  Enzyme
Novelty:  0.02938164
Score:  0.974
Data Source:  STRINGDB
GRPEL1
Tbio
Novelty:  0.00185346
Score:  0.97
Data Source:  STRINGDB
TIMM22
Tbio
Family:  Enzyme
Novelty:  0.12627933
Score:  0.97
Data Source:  STRINGDB
TIMM9
Tbio
Family:  Enzyme
Novelty:  0.02996764
Score:  0.969
Data Source:  STRINGDB
TIMM10B
Tdark
Family:  Enzyme
Novelty:  0.36798313
Score:  0.965
Data Source:  STRINGDB
Pathways (2)
Mitochondrial protein import (R-HSA-1268020)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Mitochondrial protein import
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Mitochondrial protein import
Protein localization
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
59.8
eosinophil percentage of leukocytes
1
1
1
56.2
1
1
0
1.1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
59.8
eosinophil percentage of leukocytes
1
56.2
0
1.1
2.4
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
translocase of inner mitochondrial membrane 17B
714895
Mouse
MGI:1343176
21855
Dog
translocase of inner mitochondrial membrane 17B
VGNC:49620
480908
Horse
translocase of inner mitochondrial membrane 17B
VGNC:50504
100051797
Cow
translocase of inner mitochondrial membrane 17B
VGNC:49573
540765
Species
Name
OMA
EggNOG
Inparanoid
Macaque
translocase of inner mitochondrial membrane 17B
Mouse
Dog
translocase of inner mitochondrial membrane 17B
Horse
translocase of inner mitochondrial membrane 17B
Cow
translocase of inner mitochondrial membrane 17B
Publication Statistics
PubMed Score 30.53
PubMed score by year
PubTator Score 2.57
PubTator score by year