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Tbio
PQBP1
Polyglutamine-binding protein 1

Protein Summary
Description
Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating to the transport of neuronal RNA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218224
  • ENSP00000218224
  • ENSG00000102103
  • ENST00000247140
  • ENSP00000247140
  • ENST00000376563
  • ENSP00000365747
  • ENST00000376566
  • ENSP00000365750
  • ENST00000396763
  • ENSP00000379985
  • ENST00000447146
  • ENSP00000391759

Symbol
  • NPW38
  • SHS
  • MRX2
  • MRX55
  • MRXS3
  • MRXS8
  • NPW38
  • RENS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
histone modification site profile
0.91
kinase perturbation
0.84
cellular component
0.77
tissue sample
0.72


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.22   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.22   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polyglutamine binding protein 1
VGNC:1200
739437
Macaque
polyglutamine binding protein 1
711678
Mouse
MGI:1859638
54633
Rat
RGD:1549750
302557
Dog
polyglutamine binding protein 1
VGNC:44934
480909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polyglutamine binding protein 1
Macaque
polyglutamine binding protein 1
Mouse
Rat
Dog
polyglutamine binding protein 1
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60828-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Protein-Protein Interactions (233)
1 – 10 of 233
WBP11
Tbio
Novelty: 0.03891455
p_int: 0.999274662
p_ni: 0.000725337
p_wrong: 1e-9
Score: 0.986
Data Source: BioPlex,STRINGDB
TXNL4A
Tbio
Novelty: 0.04677517
Score: 0.999
Data Source: STRINGDB
SUGP1
Tbio
Novelty: 0.00434166
Score: 0.982
Data Source: STRINGDB
CD2BP2
Tbio
Novelty: 0.01440995
Score: 0.98
Data Source: STRINGDB
SF3A2
Tbio
Novelty: 0.03658692
Score: 0.973
Data Source: STRINGDB
AQR
Tbio
Novelty: 0.00434312
Score: 0.971
Data Source: STRINGDB
HNRNPH1
Tbio
Novelty: 0.01273351
Score: 0.968
Data Source: STRINGDB
HNRNPH2
Tbio
Novelty: 0.01739858
Score: 0.962
Data Source: STRINGDB
RBM17
Tbio
Novelty: 0.04840999
Score: 0.953
Data Source: STRINGDB
HNRNPM
Tbio
Novelty: 0.0125566
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  69.22

PubMed score by year
PubTator Score  56.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer