You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PQBP1
Polyglutamine-binding protein 1

Protein Summary
Description
Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating to the transport of neuronal RNA ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218224
  • ENSP00000218224
  • ENSG00000102103
  • ENST00000247140
  • ENSP00000247140
  • ENST00000376563
  • ENSP00000365747
  • ENST00000376566
  • ENSP00000365750
  • ENST00000396763
  • ENSP00000379985
  • ENST00000447146
  • ENSP00000391759

Symbol
  • NPW38
  • SHS
  • MRX2
  • MRX55
  • MRXS3
  • MRXS8
  • NPW38
  • RENS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
histone modification site profile
0.91
kinase perturbation
0.84
cellular component
0.77
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0