Tbio TOM1 Target of Myb protein 1

Protein Summary

Description

May be involved in intracellular trafficking. Probable association with membranes. This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O60784
• B4DEL9
• B4DNA1
• Q5TIJ6
• Q86X74

Gene Name

• TOM1

Ensembl ID

• ENST00000411850
• ENSP00000413697
• ENSG00000100284
• ENST00000425375
• ENSP00000394924
• ENST00000447733
• ENSP00000398876
• ENST00000449058
• ENSP00000394466

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.95
disease perturbation	0.83
ligand (protein) perturbation	0.83
hub protein	0.79
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.09   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 176   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.09   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0