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Tdark
MRPS14
28S ribosomal protein S14, mitochondrial

Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000476371
  • ENSP00000420714
  • ENSG00000120333

Symbol
  • S14mt
  • MRP-S14
  • HSMRPS14
  • DJ262D12.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
interacting protein
0.95
kinase perturbation
0.93
histone modification site profile
0.88
gene perturbation
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.23   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.23   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (365)
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.999490961
p_ni:  0.000509039
Score:  0.986
Data Source:  BioPlex,STRINGDB
MRPS18C
Tdark
Novelty:  0.42868428
p_int:  0.984415175
p_ni:  0.015584825
Score:  0.998
Data Source:  BioPlex,STRINGDB
MRPS27
Tbio
Novelty:  0.22058227
p_int:  0.977556478
p_ni:  0.022443522
Score:  0.987
Data Source:  BioPlex,STRINGDB
MRPS15
Tdark
Novelty:  0.37070563
p_int:  0.966334384
p_ni:  0.033665614
p_wrong:  2e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
MRPS17
Tdark
Novelty:  0.46103276
p_int:  0.954286752
p_ni:  0.045713231
p_wrong:  1.7e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
p_int:  0.952899792
p_ni:  0.047100208
Score:  0.988
Data Source:  BioPlex,STRINGDB
MRPS11
Tdark
Novelty:  0.29449255
p_int:  0.92971047
p_ni:  0.07028953
Score:  0.999
Data Source:  BioPlex,STRINGDB
RPS8
Tbio
Novelty:  0.00976281
p_int:  0.9039161
p_ni:  0.0960839
Score:  0.776
Data Source:  BioPlex,STRINGDB
TRMT10B
Tdark
Family:  Enzyme
Novelty:  0.61950381
p_int:  0.860270396
p_ni:  0.139729604
Score:  0.733
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.844258676
p_ni:  0.155741324
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
1
1
40.7
platelet crit
1
1
1
27.3
feeling miserable measurement
1
1
0
5.8
27.3
body mass index
1
1
1
10.5
1
1
1
7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking initiation
1
40.7
platelet crit
1
27.3
feeling miserable measurement
0
5.8
27.3
body mass index
1
10.5
1
7
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitochondrial ribosomal protein S14
708475
Mouse
MGI:1928141
64659
Rat
RGD:1309432
289143
Dog
mitochondrial ribosomal protein S14
480061
Horse
mitochondrial ribosomal protein S14
VGNC:20354
100052668
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitochondrial ribosomal protein S14
Mouse
Rat
Dog
mitochondrial ribosomal protein S14
Horse
mitochondrial ribosomal protein S14
Publication Statistics
PubMed Score 2.23
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title