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Tbio
SLC19A2
Thiamine transporter 1

Protein Summary
Description
High-affinity transporter for the intake of thiamine. This gene encodes the thiamin transporter protein. Mutations in this gene cause thiamin-responsive megaloblastic anemia syndrome (TRMA), which is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural deafness. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236137
  • ENSP00000236137
  • ENSG00000117479
  • ENST00000367804
  • ENSP00000356778
  • ENST00000646527
  • ENSP00000495500

Symbol
  • THT1
  • TRMA
  • TC1
  • THT1
  • TRMA
  • THMD1
  • THTR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.92
histone modification site profile
0.86
pathway
0.78
microRNA
0.71
molecular function
0.67


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.8   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.8   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
1
1
0
1.3
40.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
1.3
40.1
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 19 member 2
VGNC:8103
469575
Macaque
solute carrier family 19 member 2
700684
Mouse
MGI:1928761
116914
Rat
RGD:1308611
289175
Dog
solute carrier family 19 member 2
VGNC:46260
490353
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 19 member 2
Macaque
solute carrier family 19 member 2
Mouse
Rat
Dog
solute carrier family 19 member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60779-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (203)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Vitamin B1 (thiamin) metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Vitamin B1 (thiamin) metabolism
Protein-Protein Interactions (93)
1 – 10 of 93
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.993738663
p_ni: 0.006256912
p_wrong: 0.000004425
Data Source: BioPlex
ATP5PB
Tbio
Family: Enzyme
Novelty: 0.07345384
p_int: 0.991495442
p_ni: 0.008504558
Score: 0.638
Data Source: BioPlex,STRINGDB
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.990577705
p_ni: 0.009422057
p_wrong: 2.39e-7
Data Source: BioPlex
CD27
Tbio
Novelty: 0.00090508
p_int: 0.990357235
p_ni: 0.009642765
Data Source: BioPlex
PPIE
Tbio
Family: Enzyme
Novelty: 0.01586411
p_int: 0.98956921
p_ni: 0.01043079
Data Source: BioPlex
CCR6
Tchem
Family: GPCR
Novelty: 0.00257933
p_int: 0.98925098
p_ni: 0.01071845
p_wrong: 0.00003057
Data Source: BioPlex
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00893083
p_int: 0.988749168
p_ni: 0.01114398
p_wrong: 0.000106852
Data Source: BioPlex
SLC5A5
Tbio
Family: Transporter
Novelty: 0.00139132
p_int: 0.987496646
p_ni: 0.012503354
Score: 0.292
Data Source: BioPlex,STRINGDB
SPPL2B
Tbio
Family: Enzyme
Novelty: 0.0274774
p_int: 0.987496646
p_ni: 0.012503354
Data Source: BioPlex
TNFSF18
Tbio
Novelty: 0.01423949
p_int: 0.983610901
p_ni: 0.016388984
p_wrong: 1.15e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  137.80

PubMed score by year
PubTator Score  92.84

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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