Tbio USO1 General vesicular transport factor p115

Protein Summary

Description

General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Uniprot Accession IDs

• O60763
• B2RAQ0
• Q6PK63
• Q86TB8
• Q8N592

Gene Name

• USO1

Ensembl ID

• ENST00000264904
• ENSP00000264904
• ENSG00000138768
• ENST00000514213
• ENSP00000444850

Symbol

• VDP
• TAP
• VDP
• P115

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.96
hub protein	0.9
protein complex	0.85
histone modification site profile	0.84
transcription factor binding site profile	0.84

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / General Vesicular Transport Factor P115

DTO Classes

Protein / Transporter / General Vesicular Transport Factor P115

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.23   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 342   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.23   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0