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Tbio
USO1
General vesicular transport factor p115

Protein Summary
Description
General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity. The protein encoded by this gene is a peripheral membrane protein which recycles between the cytosol and the Golgi apparatus during interphase. It is regulated by phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (COPII) vesicles during budding from the endoplasmic reticulum, where it interacts with a set of COPII vesicle-associated SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264904
  • ENSP00000264904
  • ENSG00000138768
  • ENST00000514213
  • ENSP00000444850

Symbol
  • VDP
  • TAP
  • VDP
  • P115
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
hub protein
0.9
protein complex
0.85
histone modification site profile
0.84
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.95   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 342   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.95   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 342   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cell Cycle
Cell Cycle, Mitotic
Gene Ontology Terms (21)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (263)
1 – 10 of 263
SLCO1B1
Tchem
Family: Transporter
Novelty: 0.00166289
p_int: 0.999995224
p_ni: 0.000004776
Score: 0.169
Data Source: BioPlex,STRINGDB
DDX20
Tbio
Family: Enzyme
Novelty: 0.02595469
p_int: 0.999919673
p_ni: 0.000080327
Score: 0.196
Data Source: BioPlex,STRINGDB
NUP62
Tbio
Novelty: 0.01433478
p_int: 0.999831315
p_ni: 0.000168685
Data Source: BioPlex
SETD9
Tdark
Novelty: 1.04304636
p_int: 0.999712264
p_ni: 0.000287736
Score: 0.507
Data Source: BioPlex,STRINGDB
EFNB2
Tbio
Novelty: 0.00309066
p_int: 0.999163837
p_ni: 0.000836163
Data Source: BioPlex
ZNF488
Tdark
Novelty: 0.54545455
p_int: 0.998643386
p_ni: 0.001356614
Score: 0.188
Data Source: BioPlex,STRINGDB
TXNDC11
Tbio
Novelty: 0.10709732
p_int: 0.997594541
p_ni: 0.002405459
Score: 0.261
Data Source: BioPlex,STRINGDB
C1orf94
Tdark
p_int: 0.996533672
p_ni: 0.003466328
Score: 0.169
Data Source: BioPlex,STRINGDB
SCN2B
Tbio
Family: IC
Novelty: 0.04179386
p_int: 0.99197104
p_ni: 0.00802896
Data Source: BioPlex
ANKRD22
Tdark
Novelty: 0.61888389
p_int: 0.965611097
p_ni: 0.034388835
p_wrong: 6.8e-8
Score: 0.203
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  131.95

PubMed score by year
PubTator Score  99.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer