DPM1
Dolichol-phosphate mannosyltransferase subunit 1
Protein Summary
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
- ENST00000371588
- ENSP00000360644
- ENSG00000000419
- MPDS
- CDGIE
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.95 | ||
histone modification site profile | 0.92 | ||
transcription factor binding site profile | 0.84 | ||
ligand (protein) perturbation | 0.83 | ||
virus perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.42 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 138 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.42 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 138 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (151)
Nearest Tclin Targets
Pathways (18)
Reactome (13)
KEGG (2)
PathwayCommons (1)
UniProt (1)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective DPM1 causes DPM1-CDG (CDG-1e) | ||||
Reactome | Defective DPM2 causes DPM2-CDG (CDG-1u) | ||||
Reactome | Defective DPM3 causes DPM3-CDG (CDG-1o) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective DPM1 causes DPM1-CDG (CDG-1e) | ||||
Defective DPM2 causes DPM2-CDG (CDG-1u) | ||||
Defective DPM3 causes DPM3-CDG (CDG-1o) | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (2)
Components (5)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | HGNC | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 3 | 6 | 92 | |||||
1 | 1 | 0 | 1.1 | 46.9 | |||||
2 | 2 | 1 | 1.1 | 24.5 | |||||
1 | 1 | 1 | 15.8 | ||||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
sex hormone-binding globulin measurement | 6 | 92 | |||||
0 | 1.1 | 46.9 | |||||
1 | 1.1 | 24.5 | |||||
1 | 15.8 | ||||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dolichyl-phosphate mannosyltransferase subunit 1, catalytic | VGNC:13845 | 745025 | |||||
Macaque | dolichyl-phosphate mannosyltransferase subunit 1, catalytic | 701283 | ||||||
Mouse | MGI:1330239 | 13480 | ||||||
Rat | RGD:1310120 | 296394 | ||||||
Dog | dolichyl-phosphate mannosyltransferase subunit 1, catalytic | VGNC:40070 | 477264 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dolichyl-phosphate mannosyltransferase subunit 1, catalytic | |||||
Macaque | dolichyl-phosphate mannosyltransferase subunit 1, catalytic | |||||
Mouse | ||||||
Rat | ||||||
Dog | dolichyl-phosphate mannosyltransferase subunit 1, catalytic | |||||
Publication Statistics
PubMed Score 73.42
PubMed score by year
PubTator Score 20.85
PubTator score by year
Related Publications
Text Mined References (23)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
|---|