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Tbio
DPM1
Dolichol-phosphate mannosyltransferase subunit 1

Protein Summary
Description
Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371588
  • ENSP00000360644
  • ENSG00000000419

Symbol
  • MPDS
  • CDGIE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.95
histone modification site profile
0.92
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83
virus perturbation
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.42   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.42   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (151)
DPM2
Tdark
Novelty:  0.04752556
Score:  0.997
Data Source:  Reactome,STRINGDB
DPM3
Tdark
Family:  Enzyme
Novelty:  0.05248147
Score:  0.997
Data Source:  Reactome,STRINGDB
DPAGT1
Tbio
Family:  Enzyme
Novelty:  0.00869839
Score:  0.991
Data Source:  STRINGDB
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
Score:  0.985
Data Source:  STRINGDB
ALG1
Tbio
Family:  Enzyme
Novelty:  0.012911
Score:  0.985
Data Source:  STRINGDB
ALG3
Tbio
Family:  Enzyme
Novelty:  0.0159047
Score:  0.98
Data Source:  STRINGDB
GMPPB
Tbio
Family:  Enzyme
Novelty:  0.05106206
Score:  0.979
Data Source:  STRINGDB
DOLPP1
Tdark
Family:  Enzyme
Novelty:  0.40497097
Score:  0.967
Data Source:  STRINGDB
PIGM
Tbio
Family:  Enzyme
Novelty:  0.02186069
Score:  0.958
Data Source:  STRINGDB
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (18)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective DPM1 causes DPM1-CDG (CDG-1e)
Reactome
Defective DPM2 causes DPM2-CDG (CDG-1u)
Reactome
Defective DPM3 causes DPM3-CDG (CDG-1o)
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective DPM1 causes DPM1-CDG (CDG-1e)
Defective DPM2 causes DPM2-CDG (CDG-1u)
Defective DPM3 causes DPM3-CDG (CDG-1o)
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
92
1
1
0
1.1
46.9
2
2
1
1.1
24.5
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
92
0
1.1
46.9
1
1.1
24.5
1
15.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
VGNC:13845
745025
Macaque
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
701283
Mouse
MGI:1330239
13480
Rat
RGD:1310120
296394
Dog
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
VGNC:40070
477264
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Macaque
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Mouse
Rat
Dog
dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Publication Statistics
PubMed Score 73.42
PubMed score by year
PubTator Score 20.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title