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Tchem
HPGDS
Hematopoietic prostaglandin D synthase

Protein Summary
Description
Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide. Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295256
  • ENSP00000295256
  • ENSG00000163106

Symbol
  • GSTS
  • PGDS
  • PTGDS2
  • GSTS
  • PGD2
  • PGDS
  • GSTS1
  • GSTS1-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.71
disease
0.68
molecular function
0.63
drug
0.62
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4669.59   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 97   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4669.59   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 97   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 172
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (172)
CHEMBL4238290
Rendered image for CHEMBL4238290
CHEMBL2035650
Rendered image for CHEMBL2035650
CHEMBL4238186
Rendered image for CHEMBL4238186
CHEMBL4473072
Rendered image for CHEMBL4473072
CHEMBL4247050
Rendered image for CHEMBL4247050
US9126973, 8
Rendered image for US9126973, 8
US9126973, 19
Rendered image for US9126973, 19
CHEMBL4241885
Rendered image for CHEMBL4241885
CHEMBL3181890
Rendered image for CHEMBL3181890
Protein-Protein Interactions (290)
GSR
Tclin
Family:  Enzyme
Novelty:  0.00040107
Score:  0.972
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.951
Data Source:  STRINGDB
PTGDS
Tchem
Family:  Enzyme
Novelty:  0.002111
Score:  0.947
Data Source:  STRINGDB
PTGES
Tchem
Family:  Enzyme
Novelty:  0.00146096
Score:  0.945
Data Source:  STRINGDB
PTGES2
Tchem
Family:  Enzyme
Novelty:  0.01415352
Score:  0.938
Data Source:  STRINGDB
TBXAS1
Tchem
Family:  Enzyme
Novelty:  0.0053649
Score:  0.937
Data Source:  STRINGDB
PTGS1
Tclin
Family:  Enzyme
Novelty:  0.00043214
Score:  0.934
Data Source:  STRINGDB
PTGES3
Tbio
Family:  Enzyme
Novelty:  0.0082783
Score:  0.93
Data Source:  STRINGDB
CYP2B6
Tchem
Novelty:  0.00018351
Score:  0.925
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.925
Data Source:  STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
Pathways (17)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Fatty acid metabolism
Reactome
Glutathione conjugation
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Fatty acid metabolism
Glutathione conjugation
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
92.7
puberty onset measurement
1
1
1
49.5
age at menarche
1
1
1
44.2
1
1
0
1.2
24.5
mean platelet volume
1
1
1
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
92.7
puberty onset measurement
1
49.5
age at menarche
1
44.2
0
1.2
24.5
mean platelet volume
1
24.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hematopoietic prostaglandin D synthase
VGNC:48977
743219
Macaque
hematopoietic prostaglandin D synthase
705227
Mouse
MGI:1859384
54486
Rat
RGD:69251
58962
Dog
hematopoietic prostaglandin D synthase
VGNC:54312
478481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hematopoietic prostaglandin D synthase
Macaque
hematopoietic prostaglandin D synthase
Mouse
Rat
Dog
hematopoietic prostaglandin D synthase
Publication Statistics
PubMed Score 4669.59
PubMed score by year
PubTator Score 116.36
PubTator score by year
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Related Publications
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PMID
Year
Title