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Tchem
GALR3
Galanin receptor type 3

Protein Summary
Description
Receptor for the hormone galanin (PubMed:25691535). Receptor for the hormone spexin-1 (PubMed:24517231). The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249041
  • ENSP00000249041
  • ENSG00000128310

Symbol
  • GALNR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.9
ligand (chemical)
0.86
gene perturbation
0.79
biological process
0.71
molecular function
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.56   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.56   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (238)
GAL
Tbio
Novelty:  0.0005132
Score:  0.995
Data Source:  Reactome,STRINGDB
NPY
Tbio
Novelty:  0.00012637
Score:  0.951
Data Source:  STRINGDB
SST
Tbio
Novelty:  0.00005944
Score:  0.942
Data Source:  STRINGDB
CNR1
Tclin
Family:  GPCR
Novelty:  0.00060063
Score:  0.93
Data Source:  STRINGDB
PNOC
Tbio
Novelty:  0.00132014
Score:  0.928
Data Source:  STRINGDB
NPY1R
Tchem
Family:  GPCR
Novelty:  0.00438376
Score:  0.927
Data Source:  STRINGDB
DRD3
Tclin
Family:  GPCR
Novelty:  0.00230028
Score:  0.926
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.925
Data Source:  STRINGDB
POMC
Tbio
Novelty:  0.00002436
Score:  0.925
Data Source:  STRINGDB
NPY4R
Tchem
Family:  GPCR
Novelty:  0.11465741
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
3
5
82.9
cup-to-disc ratio measurement
2
2
2
78.9
age-related hearing impairment
2
1
1
1.1
76.8
sex hormone-binding globulin measurement
4
2
4
73
brain measurement
1
1
0
11.7
70.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
82.9
cup-to-disc ratio measurement
2
78.9
age-related hearing impairment
1
1.1
76.8
sex hormone-binding globulin measurement
4
73
brain measurement
0
11.7
70.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galanin receptor 3
VGNC:5264
470205
Rat
RGD:2658
29235
Dog
galanin receptor 3
VGNC:41102
610233
Cow
galanin receptor 3
VGNC:29241
788463
Pig
galanin receptor 3
100623444
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galanin receptor 3
Rat
Dog
galanin receptor 3
Cow
galanin receptor 3
Pig
galanin receptor 3
Publication Statistics
PubMed Score 30.56
PubMed score by year
PubTator Score 22.04
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title