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Tbio
SNX2
Sorting nexin-2

Protein Summary
Description
Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000379516
  • ENSP00000368831
  • ENSG00000205302
  • ENST00000514949
  • ENSP00000421663

Symbol
  • TRG-9
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.9
protein complex
0.68
histone modification site profile
0.67
tissue sample
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.13   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.13   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
50.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
50.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 2
VGNC:4170
462022
Macaque
sorting nexin 2
700507
Mouse
MGI:1915054
67804
Rat
RGD:1310291
291464
Dog
sorting nexin 2
VGNC:46629
474657
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sorting nexin 2
Macaque
sorting nexin 2
Mouse
Rat
Dog
sorting nexin 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60749-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Golgi Associated Vesicle Biogenesis (R-HSA-432722)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Reactome
trans-Golgi Network Vesicle Budding
Name
Explore in Pharos
Explore in Source
Golgi Associated Vesicle Biogenesis
Membrane Trafficking
Vesicle-mediated transport
trans-Golgi Network Vesicle Budding
Gene Ontology Terms (25)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (166)
1 – 10 of 166
SNX1
Tbio
Novelty: 0.01267973
p_int: 0.999997789
p_ni: 0.000002211
Score: 0.976
Data Source: BioPlex,STRINGDB
C1orf87
Tbio
Novelty: 0.03162594
p_int: 0.999992567
p_ni: 0.000007433
Score: 0.239
Data Source: BioPlex,STRINGDB
KLHL1
Tbio
Novelty: 0.05206893
p_int: 0.999962503
p_ni: 0.000037497
Data Source: BioPlex
HYOU1
Tbio
Novelty: 0.00833649
p_int: 0.999431336
p_ni: 0.000568664
Data Source: BioPlex
POTEB
Tdark
Novelty: 0.48864918
p_int: 0.99792886
p_ni: 0.00207114
Data Source: BioPlex
HENMT1
Tdark
Family: Enzyme
Novelty: 0.17427834
p_int: 0.997867296
p_ni: 0.002132704
Score: 0.167
Data Source: BioPlex,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.997852536
p_ni: 0.002147464
Score: 0.315
Data Source: BioPlex,STRINGDB
C11orf42
Tdark
Novelty: 3.71428571
p_int: 0.991861947
p_ni: 0.008138053
Score: 0.214
Data Source: BioPlex,STRINGDB
TCTEX1D2
Tbio
Novelty: 0.15075459
p_int: 0.989933735
p_ni: 0.010066265
Score: 0.181
Data Source: BioPlex,STRINGDB
DNM3
Tbio
Novelty: 0.02365643
p_int: 0.989805942
p_ni: 0.010194057
p_wrong: 1e-9
Score: 0.301
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.13

PubMed score by year
PubTator Score  25.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer