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Tclin
HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Protein Summary
Description
Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. The membrane protein encoded by this gene is a hyperpolarization-activated cation channel that contributes to the native pacemaker currents in heart and neurons. The encoded protein can homodimerize or heterodimerize with other pore-forming subunits to form a potassium channel. This channel may act as a receptor for sour tastes. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303230
  • ENSP00000307342
  • ENSG00000164588

Symbol
  • BCNG1
  • BCNG1
  • HAC-2
  • BCNG-1
  • EIEE24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
protein domain
0.97
gene perturbation
0.91
microRNA
0.74
cell line
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.32   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 348   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.32   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 348   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (22)
1 – 10 of 22
HCN2
Tclin
Family:  IC
Novelty:  0.02421034
Score:  0.858
Data Source:  STRINGDB
HCN4
Tclin
Family:  IC
Novelty:  0.0021957
Score:  0.831
Data Source:  STRINGDB
PEX5L
Tbio
Novelty:  0.01922466
Score:  0.768
Data Source:  STRINGDB
MARCH7
Tbio
Family:  Enzyme
Novelty:  0.03358004
Score:  0.718
Data Source:  STRINGDB
KCTD3
Tdark
Novelty:  0.33599775
Score:  0.683
Data Source:  STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.625
Data Source:  STRINGDB
SHKBP1
Tbio
Novelty:  0.00235279
Score:  0.59
Data Source:  STRINGDB
KCNQ2
Tclin
Family:  IC
Novelty:  0.00209684
Score:  0.575
Data Source:  STRINGDB
FLNA
Tbio
Novelty:  0.00156479
Score:  0.548
Data Source:  STRINGDB
NEDD4L
Tbio
Family:  Enzyme
Novelty:  0.00250567
Score:  0.534
Data Source:  STRINGDB
Pathways (49)
HCN channels (R-HSA-1296061)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
HCN channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
HCN channels
Neuronal System
Potassium Channels
Gene Ontology Terms (20)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
9
6
2
1.1
74.6
age at first sexual intercourse measurement
1
1
1
53.7
smoking status measurement
1
1
1
44.2
smoking initiation
1
1
1
35
1
2
0
1.1
32.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
74.6
age at first sexual intercourse measurement
1
53.7
smoking status measurement
1
44.2
smoking initiation
1
35
0
1.1
32.6
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hyperpolarization activated cyclic nucleotide gated potassium channel 1
VGNC:13507
471552
Mouse
MGI:1096392
15165
Rat
RGD:620688
84390
Dog
hyperpolarization activated cyclic nucleotide gated potassium channel 1
VGNC:41620
612434
Horse
hyperpolarization activated cyclic nucleotide gated potassium channel 1
VGNC:18711
100064345
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hyperpolarization activated cyclic nucleotide gated potassium channel 1
Mouse
Rat
Dog
hyperpolarization activated cyclic nucleotide gated potassium channel 1
Horse
hyperpolarization activated cyclic nucleotide gated potassium channel 1
Publication Statistics
PubMed Score 44.32
PubMed score by year
PubTator Score 135.38
PubTator score by year
Patents
Patents by year