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Tchem
PLA2G6
85/88 kDa calcium-independent phospholipase A2

Protein Summary
Description
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity. The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332509
  • ENSP00000333142
  • ENSG00000184381
  • ENST00000335539
  • ENSP00000335149
  • ENST00000402064
  • ENSP00000386100

Symbol
  • PLPLA9
  • GVI
  • PLA2
  • INAD1
  • NBIA2
  • iPLA2
  • NBIA2A
  • NBIA2B
  • PARK14
  • PNPLA9
  • CaI-PLA2
  • IPLA2-VIA
  • iPLA2beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
metabolite
0.94
disease perturbation
0.87
trait
0.86
transcription factor binding site profile
0.86


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.96   (req: < 5)
Gene RIFs: 104   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.96   (req: >= 5)
Gene RIFs: 104   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0