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Tbio
CDC14B
Dual specificity protein phosphatase CDC14B

Protein Summary
Description
Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375240
  • ENSP00000364388
  • ENSG00000081377
  • ENST00000375241
  • ENSP00000364389
  • ENST00000375242
  • ENSP00000364390
  • ENST00000463569
  • ENSP00000420572
  • ENST00000474602
  • ENSP00000417897

Symbol
  • CDC14B3
  • Cdc14B1
  • Cdc14B2
  • hCDC14B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
kinase perturbation
0.93
protein domain
0.85
virus perturbation
0.83
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
97.2
appendicular lean mass
2
1
2
95.6
cognitive function measurement
1
1
1
87.3
body height
1
1
1
39.7
intelligence
2
1
1
5.9
31.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
97.2
appendicular lean mass
2
95.6
cognitive function measurement
1
87.3
body height
1
39.7
intelligence
1
5.9
31.5
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
MAPK family signaling cascades (R-HSA-5683057)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MAPK family signaling cascades
Reactome
MAPK6/MAPK4 signaling
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
MAPK family signaling cascades
MAPK6/MAPK4 signaling
Signal Transduction
Protein-Protein Interactions (110)
1 – 10 of 110
FZR1
Tbio
Novelty: 0.01599606
Score: 0.974
Data Source: STRINGDB
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
Score: 0.949
Data Source: Reactome,STRINGDB
CCND3
Tchem
Novelty: 0.00223085
Score: 0.918
Data Source: STRINGDB
CDC14A
Tbio
Family: Enzyme
Novelty: 0.00416647
Score: 0.904
Data Source: STRINGDB
PKMYT1
Tchem
Family: Kinase
Novelty: 0.03025516
Score: 0.832
Data Source: STRINGDB
CDK1
Tchem
Family: Kinase
Novelty: 0.00040776
Score: 0.752
Data Source: STRINGDB
CDC27
Tbio
Novelty: 0.00589846
Score: 0.751
Data Source: STRINGDB
PLK1
Tchem
Family: Kinase
Novelty: 0.00062799
Score: 0.731
Data Source: STRINGDB
CDC23
Tbio
Novelty: 0.0168525
Score: 0.697
Data Source: STRINGDB
PLK2
Tchem
Family: Kinase
Novelty: 0.00750465
Score: 0.686
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.41

PubMed score by year
PubTator Score  20.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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