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Tbio
SLC24A1
Sodium/potassium/calcium exchanger 1

Protein Summary
Description
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. The encoded protein plays an important role in sodium/calcium exchange in retinal rod and cone photoreceptors by mediating the extrusion of one calcium ion and one potassium ion in exchange for four sodium ions. Mutations in this gene may play a role in congenital stationary night blindness. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261892
  • ENSP00000261892
  • ENSG00000074621
  • ENST00000339868
  • ENSP00000341837
  • ENST00000399033
  • ENSP00000381991
  • ENST00000546330
  • ENSP00000439190

Symbol
  • KIAA0702
  • NCKX1
  • NCKX
  • RODX
  • NCKX1
  • CSNB1D
  • HsT17412
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.94
gene perturbation
0.89
molecular function
0.84
kinase perturbation
0.76
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.9   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.9   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (45)
1 – 10 of 45
RCVRN
Tbio
Novelty:  0.00266222
Score:  0.732
Data Source:  STRINGDB
CNGA1
Tchem
Family:  IC
Novelty:  0.00848214
Score:  0.707
Data Source:  STRINGDB
GNGT2
Tbio
Novelty:  0.0468008
Score:  0.698
Data Source:  STRINGDB
SLC8A1
Tchem
Family:  Transporter
Novelty:  0.0023933
Score:  0.685
Data Source:  STRINGDB
PDE6A
Tclin
Family:  Enzyme
Novelty:  0.02680494
Score:  0.659
Data Source:  STRINGDB
PDE6H
Tclin
Family:  Enzyme
Novelty:  0.0524804
Score:  0.653
Data Source:  STRINGDB
CNGA3
Tchem
Family:  IC
Novelty:  0.00818181
Score:  0.641
Data Source:  STRINGDB
LRIT3
Tbio
Novelty:  0.2385612
Score:  0.615
Data Source:  STRINGDB
GPR179
Tdark
Family:  GPCR
Novelty:  0.09278403
Score:  0.593
Data Source:  STRINGDB
CABP4
Tbio
Novelty:  0.04472327
Score:  0.589
Data Source:  STRINGDB
Pathways (17)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
G alpha (i) signalling events
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)
Disease
Disorders of transmembrane transporters
G alpha (i) signalling events
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
3
3
98
hemoglobin measurement
4
4
4
90.4
self reported educational attainment
5
5
4
6.4
90.3
monocyte percentage of leukocytes
1
1
1
81.1
mathematical ability
2
2
2
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
3
98
hemoglobin measurement
4
90.4
self reported educational attainment
4
6.4
90.3
monocyte percentage of leukocytes
1
81.1
mathematical ability
2
79.4
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 24 member 1
VGNC:7777
453521
Macaque
solute carrier family 24 member 1
713970
Mouse
MGI:2384871
214111
Rat
RGD:620080
56814
Dog
solute carrier family 24 member 1
VGNC:46285
100683168
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 24 member 1
Macaque
solute carrier family 24 member 1
Mouse
Rat
Dog
solute carrier family 24 member 1
Publication Statistics
PubMed Score 97.90
PubMed score by year
PubTator Score 46.03
PubTator score by year