Protein Summary
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
- ENST00000358694
- ENSP00000351527
- ENSG00000198561
- ENST00000361332
- ENSP00000354823
- ENST00000361391
- ENSP00000354785
- ENST00000361796
- ENSP00000354907
- ENST00000399050
- ENSP00000382004
- ENST00000415361
- ENSP00000403518
- ENST00000426142
- ENSP00000409930
- ENST00000428599
- ENSP00000413586
- ENST00000524630
- ENSP00000436543
- ENST00000525902
- ENSP00000434672
- ENST00000526357
- ENSP00000433334
- ENST00000526772
- ENSP00000433158
- ENST00000526938
- ENSP00000432041
- ENST00000527467
- ENSP00000434900
- ENST00000528232
- ENSP00000435266
- ENST00000528621
- ENSP00000432243
- ENST00000529526
- ENSP00000436323
- ENST00000529873
- ENSP00000435494
- ENST00000529986
- ENSP00000437156
- ENST00000530094
- ENSP00000437327
- ENST00000530748
- ENSP00000436744
- ENST00000531014
- ENSP00000432623
- ENST00000532245
- ENSP00000434017
- ENST00000532463
- ENSP00000432075
- ENST00000532649
- ENSP00000435379
- ENST00000532787
- ENSP00000434949
- ENST00000532844
- ENSP00000433276
- ENST00000533667
- ENSP00000437051
- ENST00000534579
- ENSP00000435789
- KIAA0384
- CAS
- p120
- BCDS2
- CTNND
- P120CAS
- P120CTN
- p120(CAS)
- p120(CTN)
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
ligand (protein) perturbation | 1 | ||
hub protein | 0.99 | ||
kinase perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 362.36 (req: < 5)
Gene RIFs: 188 (req: <= 3)
Antibodies: 962 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 362.36 (req: >= 5)
Gene RIFs: 188 (req: > 3)
Antibodies: 962 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0