You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CTNND1
Catenin delta-1

Protein Summary
Description
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358694
  • ENSP00000351527
  • ENSG00000198561
  • ENST00000361332
  • ENSP00000354823
  • ENST00000361391
  • ENSP00000354785
  • ENST00000361796
  • ENSP00000354907
  • ENST00000399050
  • ENSP00000382004
  • ENST00000415361
  • ENSP00000403518
  • ENST00000426142
  • ENSP00000409930
  • ENST00000428599
  • ENSP00000413586
  • ENST00000524630
  • ENSP00000436543
  • ENST00000525902
  • ENSP00000434672
  • ENST00000526357
  • ENSP00000433334
  • ENST00000526772
  • ENSP00000433158
  • ENST00000526938
  • ENSP00000432041
  • ENST00000527467
  • ENSP00000434900
  • ENST00000528232
  • ENSP00000435266
  • ENST00000528621
  • ENSP00000432243
  • ENST00000529526
  • ENSP00000436323
  • ENST00000529873
  • ENSP00000435494
  • ENST00000529986
  • ENSP00000437156
  • ENST00000530094
  • ENSP00000437327
  • ENST00000530748
  • ENSP00000436744
  • ENST00000531014
  • ENSP00000432623
  • ENST00000532245
  • ENSP00000434017
  • ENST00000532463
  • ENSP00000432075
  • ENST00000532649
  • ENSP00000435379
  • ENST00000532787
  • ENSP00000434949
  • ENST00000532844
  • ENSP00000433276
  • ENST00000533667
  • ENSP00000437051
  • ENST00000534579
  • ENSP00000435789

Symbol
  • KIAA0384
  • CAS
  • p120
  • BCDS2
  • CTNND
  • P120CAS
  • P120CTN
  • p120(CAS)
  • p120(CTN)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
ligand (protein) perturbation
1
hub protein
0.99
kinase perturbation
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.99   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 962   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 336.99   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 962   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (224)
CDH1
Tbio
Novelty:  0.00010629
p_int:  0.999822516
p_ni:  0.00006434
p_wrong:  0.000113145
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CDH8
Tbio
Novelty:  0.04055999
p_int:  0.999371343
p_ni:  0.000628657
Score:  0.943
Data Source:  BioPlex,STRINGDB
ZBTB33
Tbio
Family:  TF
Novelty:  0.01327474
p_int:  0.998635266
p_ni:  0.001364734
Score:  0.997
Data Source:  BioPlex,STRINGDB
CTNNA3
Tbio
Novelty:  0.01472452
p_int:  0.98791659
p_ni:  0.01208341
Score:  0.57
Data Source:  BioPlex,STRINGDB
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.949080033
p_ni:  0.050919967
Score:  0.991
Data Source:  BioPlex,Reactome,STRINGDB
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
p_int:  0.879260099
p_ni:  0.116617942
p_wrong:  0.004121959
Data Source:  BioPlex
COL1A1
Tbio
Novelty:  0.00063584
p_int:  0.820799842
p_ni:  0.177270794
p_wrong:  0.001929364
Data Source:  BioPlex
CTNNB1
Tchem
Novelty:  0.0000744
p_int:  0.804618377
p_ni:  0.195381623
Score:  0.988
Data Source:  BioPlex,Reactome,STRINGDB
FER
Tclin
Family:  Kinase
Novelty:  0.01531184
Score:  0.999
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
1 – 5 of 5
ERBB2
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
MET
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
FYN
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
EGFR
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  2
YES1
Tclin
Family:  Kinase
KEGG Distance:  1
Common Pathways:  1
Pathways (32)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
3
4
91
neuroticism measurement
5
5
3
6.3
78.5
mean corpuscular hemoglobin concentration
1
1
1
75.2
wellbeing measurement
3
3
3
73.2
self reported educational attainment
1
1
1
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
91
neuroticism measurement
3
6.3
78.5
mean corpuscular hemoglobin concentration
1
75.2
wellbeing measurement
3
73.2
self reported educational attainment
1
69.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
catenin delta 1
VGNC:53059
743685
Macaque
catenin delta 1
704212
Mouse
MGI:105100
12388
Rat
RGD:1305643
311163
Horse
catenin delta 1
VGNC:16941
100067065
Species
Name
OMA
EggNOG
Inparanoid
Chimp
catenin delta 1
Macaque
catenin delta 1
Mouse
Rat
Horse
catenin delta 1
Publication Statistics
PubMed Score 336.99
PubMed score by year
PubTator Score 355.55
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title