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Tbio
TPST2
Protein-tyrosine sulfotransferase 2

Protein Classes
Protein Summary
Description
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. The protein encoded by this gene catalyzes the O-sulfation of tyrosine residues within acidic regions of proteins. The encoded protein is a type II integral membrane protein found in the Golgi body. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2018]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338754
  • ENSP00000339813
  • ENSG00000128294
  • ENST00000398110
  • ENSP00000381180
  • ENST00000403880
  • ENSP00000385192

Symbol
  • TPST-2
  • TANGO13B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
disease perturbation
0.9
small molecule perturbation
0.73
transcription factor
0.73
transcription factor perturbation
0.68


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.09   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.09   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosylprotein sulfotransferase 2
VGNC:6161
458726
Macaque
tyrosylprotein sulfotransferase 2
715338
Mouse
MGI:1309516
22022
Rat
RGD:1305331
288719
Dog
tyrosylprotein sulfotransferase 2
VGNC:47756
486332
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosylprotein sulfotransferase 2
Macaque
tyrosylprotein sulfotransferase 2
Mouse
Rat
Dog
tyrosylprotein sulfotransferase 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60704-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (115)
1 – 10 of 115
TPST1
Tbio
Family:  Enzyme
Novelty:  0.03915379
p_int:  0.99999988
p_ni:  7.1e-8
p_wrong:  4.9e-8
Data Source:  BioPlex
MCOLN1
Tchem
Family:  IC
Novelty:  0.00442768
p_int:  0.999980798
p_ni:  0.000016168
p_wrong:  0.000003034
Data Source:  BioPlex
NDC80
Tbio
Novelty:  0.00331814
p_int:  0.999979209
p_ni:  0.000020791
Data Source:  BioPlex
ATP2B3
Tbio
Family:  Transporter
Novelty:  0.00901493
p_int:  0.999773419
p_ni:  0.000226581
Data Source:  BioPlex
DSN1
Tbio
Novelty:  0.05336903
p_int:  0.999757065
p_ni:  0.000242935
Data Source:  BioPlex
TBC1D20
Tbio
Novelty:  0.08651866
p_int:  0.999717067
p_ni:  0.000007341
p_wrong:  0.000275592
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.99963561
p_ni:  0.000364389
p_wrong:  1e-9
Data Source:  BioPlex
CSGALNACT2
Tbio
Family:  Enzyme
Novelty:  0.0770692
p_int:  0.999593396
p_ni:  0.000406604
Data Source:  BioPlex
KDM8
Tbio
Family:  Epigenetic
Novelty:  0.03368031
p_int:  0.999591523
p_ni:  0.00039994
p_wrong:  0.000008537
Data Source:  BioPlex
NSL1
Tbio
Novelty:  0.01396984
p_int:  0.999564195
p_ni:  0.000434924
p_wrong:  8.8e-7
Data Source:  BioPlex
Publication Statistics
PubMed Score  40.09

PubMed score by year
PubTator Score  17.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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