UGDH
UDP-glucose 6-dehydrogenase
Protein Summary
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
- ENST00000316423
- ENSP00000319501
- ENSG00000109814
- ENST00000501493
- ENSP00000422909
- ENST00000506179
- ENSP00000421757
- ENST00000507089
- ENSP00000426560
- GDH
- UGD
- UDPGDH
- UDP-GlcDH
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
kinase perturbation | 0.91 | ||
transcription factor perturbation | 0.88 | ||
histone modification site profile | 0.86 | ||
PubMedID | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 368.03 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 283 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 368.03 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 283 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (132)
GGH
Family: Enzyme
Novelty: 0.00258239
p_int: 0.997556479
p_ni: 0.002443521
Score: 0.674
Data Source: BioPlex,STRINGDB
RNF7
Novelty: 0.02532658
p_int: 0.994902165
p_ni: 0.005097835
Score: 0.161
Data Source: BioPlex,STRINGDB
FAS
Novelty: 0.00043286
p_int: 0.981620059
p_ni: 0.018379941
Score: 0.183
Data Source: BioPlex,STRINGDB
FAM174A
Novelty: 0.30693139
p_int: 0.939975956
p_ni: 0.060023898
p_wrong: 1.46e-7
Data Source: BioPlex
NAAA
Family: Enzyme
Novelty: 0.00368876
p_int: 0.921139627
p_ni: 0.078860354
p_wrong: 1.9e-8
Score: 0.153
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (31)
Reactome (5)
KEGG (4)
PathwayCommons (2)
UniProt (1)
WikiPathways (19)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Formation of the active cofactor, UDP-glucuronate | ||||
Reactome | Glucuronidation | ||||
Reactome | Metabolism | ||||
Reactome | Phase II - Conjugation of compounds | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Formation of the active cofactor, UDP-glucuronate | ||||
Glucuronidation | ||||
Metabolism | ||||
Phase II - Conjugation of compounds | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (4)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 13 | 10 | 18 | 8.1 | 98.8 | ||||
alcohol use disorder measurement | 5 | 5 | 2 | 7.9 | 97 | ||||
bitter alcoholic beverage consumption measurement | 1 | 1 | 1 | 80.8 | |||||
serum gamma-glutamyl transferase measurement | 1 | 1 | 1 | 75.6 | |||||
longitudinal alcohol consumption measurement | 1 | 1 | 1 | 71.9 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 18 | 8.1 | 98.8 | ||||
alcohol use disorder measurement | 2 | 7.9 | 97 | ||||
bitter alcoholic beverage consumption measurement | 1 | 80.8 | |||||
serum gamma-glutamyl transferase measurement | 1 | 75.6 | |||||
longitudinal alcohol consumption measurement | 1 | 71.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | UDP-glucose 6-dehydrogenase | VGNC:2958 | 471171 | |||||
Macaque | UDP-glucose 6-dehydrogenase | 699500 | ||||||
Mouse | MGI:1306785 | 22235 | ||||||
Rat | RGD:621879 | 83472 | ||||||
Dog | UDP-glucose 6-dehydrogenase | VGNC:48117 | 479107 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | UDP-glucose 6-dehydrogenase | |||||
Macaque | UDP-glucose 6-dehydrogenase | |||||
Mouse | ||||||
Rat | ||||||
Dog | UDP-glucose 6-dehydrogenase | |||||
Publication Statistics
PubMed Score 368.03
PubMed score by year
PubTator Score 89.92
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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