Tbio UGDH UDP-glucose 6-dehydrogenase

Protein Summary

Description

Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• O60701
• B3KUU2
• B4DN25
• O60589
• UDP-Glc dehydrogenase

Gene Name

• UGDH

Ensembl ID

• ENST00000316423
• ENSP00000319501
• ENSG00000109814
• ENST00000501493
• ENSP00000422909
• ENST00000506179
• ENSP00000421757
• ENST00000507089
• ENSP00000426560

Symbol

• GDH
• UGD
• UDPGDH
• UDP-GlcDH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
kinase perturbation	0.91
transcription factor perturbation	0.88
histone modification site profile	0.86
PubMedID	0.83

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.97   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 283   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.97   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (2)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
peripheral arterial disease	EFO_0004265	1	1	0	1789.8	31.7
traffic air pollution measurement	EFO_0007908	1	1	0	1789.8	31.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
peripheral arterial disease	EFO_0004265	0	1789.8	31.7
traffic air pollution measurement	EFO_0007908	0	1789.8	31.7

Reset Zoom  Beta Count   Odds Ratio

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	UDP-glucose 6-dehydrogenase	VGNC:2958	471171
Macaque	UDP-glucose 6-dehydrogenase		699500
Mouse	UDP-glucose dehydrogenase	MGI:1306785	22235
Rat	UDP-glucose 6-dehydrogenase	RGD:621879	83472
Dog	UDP-glucose 6-dehydrogenase	VGNC:48117	479107

Species	Name	OMA	EggNOG	Inparanoid
Chimp	UDP-glucose 6-dehydrogenase
Macaque	UDP-glucose 6-dehydrogenase
Mouse	UDP-glucose dehydrogenase
Rat	UDP-glucose 6-dehydrogenase
Dog	UDP-glucose 6-dehydrogenase

Protein Structure (15 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60701-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (31)

Reactome (5)

KEGG (4)

PathwayCommons (2)

UniProt (1)

WikiPathways (19)

Biological oxidations (R-HSA-211859)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	Formation of the active cofactor, UDP-glucuronate	3 targets	R-HSA-173599
Reactome	Glucuronidation	24 targets	R-HSA-156588
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Phase II - Conjugation of compounds	109 targets	R-HSA-156580

Name	Explore in Pharos	Explore in Source
Biological oxidations	221 targets	R-HSA-211859
Formation of the active cofactor, UDP-glucuronate	3 targets	R-HSA-173599
Glucuronidation	24 targets	R-HSA-156588
Metabolism	2112 targets	R-HSA-1430728
Phase II - Conjugation of compounds	109 targets	R-HSA-156580

Gene Ontology Terms (11)

Functions (3)

Components (4)

Processes (4)

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1 – 3 of 3

GO Term	Evidence	Assigned by
electron transfer activity	Traceable Author Statement (TAS)	UniProtKB
UDP-glucose 6-dehydrogenase activity	Traceable Author Statement (TAS)	Reactome
NAD binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (132)

Explore Interacting Targets

1 – 10 of 132

• See Interactions on String-DB

GGH

Tchem

Family: Enzyme

Novelty: 0.00258239

p_int: 0.997556479

p_ni: 0.002443521

Score: 0.674

Data Source: BioPlex,STRINGDB

IL25

Tbio

Novelty: 0.01620324

p_int: 0.996541755

p_ni: 0.003458244

p_wrong: 1e-9

Data Source: BioPlex

RNF7

Tbio

Novelty: 0.02532658

p_int: 0.994902165

p_ni: 0.005097835

Score: 0.161

Data Source: BioPlex,STRINGDB

LAMP3

Tbio

Novelty: 0.01677383

p_int: 0.984074091

p_ni: 0.015925909

Data Source: BioPlex

FAS

Tbio

Novelty: 0.00043286

p_int: 0.981620059

p_ni: 0.018379941

Score: 0.183

Data Source: BioPlex,STRINGDB

FAM174A

Tdark

Novelty: 0.30693139

p_int: 0.939975956

p_ni: 0.060023898

p_wrong: 1.46e-7

Data Source: BioPlex

NAAA

Tchem

Family: Enzyme

Novelty: 0.00368876

p_int: 0.921139627

p_ni: 0.078860354

p_wrong: 1.9e-8

Score: 0.153

Data Source: BioPlex,STRINGDB

LCN6

Tbio

Novelty: 0.11406686

p_int: 0.907539029

p_ni: 0.092460971

Data Source: BioPlex

TMEM9

Tbio

Novelty: 0.06916197

p_int: 0.818792289

p_ni: 0.181207711

Data Source: BioPlex

GRP

Tbio

Novelty: 0.00034247

p_int: 0.758101302

p_ni: 0.241898698

Data Source: BioPlex

Publication Statistics

PubMed Score  363.97

PubMed score by year

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PubTator Score  89.92

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Allosteric enzyme
Alternative splicing
Complete proteome
NAD
Oxidoreductase
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

peripheral arterial disease
traffic air pollution measurement

MGI Phenotype Find Similar Targets

craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
mortality/aging
vision/eye phenotype