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Tbio
UGDH
UDP-glucose 6-dehydrogenase

Protein Summary
Description
Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316423
  • ENSP00000319501
  • ENSG00000109814
  • ENST00000501493
  • ENSP00000422909
  • ENST00000506179
  • ENSP00000421757
  • ENST00000507089
  • ENSP00000426560

Symbol
  • GDH
  • UGD
  • UDPGDH
  • UDP-GlcDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
kinase perturbation
0.91
transcription factor perturbation
0.88
histone modification site profile
0.86
PubMedID
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
View Data
 GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.97   (req: < 5)
View Publications
Gene RIFs: 28   (req: <= 3)
View Gene RIFs
Antibodies: 283   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 363.97   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
peripheral arterial disease
EFO_0004265
1
1
0
1789.8
31.7
traffic air pollution measurement
EFO_0007908
1
1
0
1789.8
31.7
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
peripheral arterial disease
EFO_0004265
0
1789.8
31.7
traffic air pollution measurement
EFO_0007908
0
1789.8
31.7
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose 6-dehydrogenase
VGNC:2958
471171
Macaque
UDP-glucose 6-dehydrogenase
699500
Mouse
UDP-glucose dehydrogenase
MGI:1306785
22235
Rat
UDP-glucose 6-dehydrogenase
RGD:621879
83472
Dog
UDP-glucose 6-dehydrogenase
VGNC:48117
479107
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose 6-dehydrogenase
Macaque
UDP-glucose 6-dehydrogenase
Mouse
UDP-glucose dehydrogenase
Rat
UDP-glucose 6-dehydrogenase
Dog
UDP-glucose 6-dehydrogenase
Protein Data Bank (15)
1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
221 targets
R-HSA-211859
Reactome
Formation of the active cofactor, UDP-glucuronate
3 targets
R-HSA-173599
Reactome
Glucuronidation
24 targets
R-HSA-156588
Reactome
Metabolism
2112 targets
R-HSA-1430728
Reactome
Phase II - Conjugation of compounds
109 targets
R-HSA-156580
Name
Explore in Pharos
Explore in Source
Biological oxidations
221 targets
R-HSA-211859
Formation of the active cofactor, UDP-glucuronate
3 targets
R-HSA-173599
Glucuronidation
24 targets
R-HSA-156588
Metabolism
2112 targets
R-HSA-1430728
Phase II - Conjugation of compounds
109 targets
R-HSA-156580
Protein-Protein Interactions (132)
1 – 10 of 132
GGH
Tchem
Family: Enzyme
Novelty: 0.00258239
p_int: 0.997556479
p_ni: 0.002443521
Score: 0.674
Data Source: BioPlex,STRINGDB
IL25
Tbio
Novelty: 0.01620324
p_int: 0.996541755
p_ni: 0.003458244
p_wrong: 1e-9
Data Source: BioPlex
RNF7
Tbio
Novelty: 0.02532658
p_int: 0.994902165
p_ni: 0.005097835
Score: 0.161
Data Source: BioPlex,STRINGDB
LAMP3
Tbio
Novelty: 0.01677383
p_int: 0.984074091
p_ni: 0.015925909
Data Source: BioPlex
FAS
Tbio
Novelty: 0.00043286
p_int: 0.981620059
p_ni: 0.018379941
Score: 0.183
Data Source: BioPlex,STRINGDB
FAM174A
Tdark
Novelty: 0.30693139
p_int: 0.939975956
p_ni: 0.060023898
p_wrong: 1.46e-7
Data Source: BioPlex
NAAA
Tchem
Family: Enzyme
Novelty: 0.00368876
p_int: 0.921139627
p_ni: 0.078860354
p_wrong: 1.9e-8
Score: 0.153
Data Source: BioPlex,STRINGDB
LCN6
Tbio
Novelty: 0.11406686
p_int: 0.907539029
p_ni: 0.092460971
Data Source: BioPlex
TMEM9
Tbio
Novelty: 0.06916197
p_int: 0.818792289
p_ni: 0.181207711
Data Source: BioPlex
GRP
Tbio
Novelty: 0.00034247
p_int: 0.758101302
p_ni: 0.241898698
Data Source: BioPlex
Publication Statistics
PubMed Score  363.97

PubMed score by year
PubTator Score  89.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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