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Tchem
PRMT3
Protein arginine N-methyltransferase 3

Protein Summary
Description
Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins. This gene belongs to the protein arginine methyltransferase (PRMT) family. The encoded enzyme catalyzes the methylation of guanidino nitrogens of arginyl residues of proteins. The enzyme acts on 40S ribosomal protein S2 (rpS2), which is its major in-vivo substrate, and is involved in the proper maturation of the 80S ribosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331079
  • ENSP00000331879
  • ENSG00000185238
  • ENST00000437750
  • ENSP00000397766

Symbol
  • HRMT1L3
  • HRMT1L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.95
transcription factor binding site profile
0.89
histone modification site profile
0.82
kinase perturbation
0.81
cell type or tissue
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.05   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.05   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0