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Tbio
REV3L
DNA polymerase zeta catalytic subunit

Protein Summary
Description
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358835
  • ENSP00000351697
  • ENSG00000009413
  • ENST00000368802
  • ENSP00000357792
  • ENST00000368805
  • ENSP00000357795
  • ENST00000435970
  • ENSP00000402003

Symbol
  • POLZ
  • REV3
  • POLZ
  • REV3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.92
histone modification site profile
0.84
virus perturbation
0.83
molecular function
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.04   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 252.04   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
POLD2
Tbio
Family:  Enzyme
Novelty:  0.05932998
p_int:  0.999999995
p_ni:  5e-9
Score:  0.965
Data Source:  BioPlex,STRINGDB
MAD2L2
Tbio
Novelty:  0.01091072
Score:  0.999
Data Source:  Reactome,STRINGDB
REV1
Tbio
Novelty:  0.00294652
Score:  0.999
Data Source:  Reactome,STRINGDB
POLD3
Tbio
Family:  Enzyme
Novelty:  0.02646621
Score:  0.988
Data Source:  STRINGDB
POLE
Tclin
Family:  Enzyme
Novelty:  0.00371129
Score:  0.987
Data Source:  STRINGDB
POLK
Tbio
Family:  Enzyme
Novelty:  0.01378154
Score:  0.983
Data Source:  Reactome,STRINGDB
POLI
Tchem
Family:  Enzyme
Novelty:  0.00042246
Score:  0.978
Data Source:  Reactome,STRINGDB
PCNA
Tchem
Novelty:  0.03909539
Score:  0.977
Data Source:  Reactome,STRINGDB
POLH
Tchem
Family:  Enzyme
Novelty:  0.00458533
Score:  0.963
Data Source:  STRINGDB
POLE3
Tbio
Family:  Enzyme
Novelty:  0.09657513
Score:  0.957
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Translesion synthesis by POLI
Reactome
Translesion synthesis by POLK
Reactome
Translesion synthesis by REV1
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Translesion synthesis by POLI
Translesion synthesis by POLK
Translesion synthesis by REV1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (30)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
3
2
1.1
93.9
3
3
0
1.3
88.1
smoking behavior
1
2
2
87.1
mean corpuscular hemoglobin concentration
1
1
1
83.2
blood metabolite measurement
2
2
2
80.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
1.1
93.9
0
1.3
88.1
smoking behavior
2
87.1
mean corpuscular hemoglobin concentration
1
83.2
blood metabolite measurement
2
80.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
REV3 like, DNA directed polymerase zeta catalytic subunit
VGNC:9601
462942
Macaque
REV3 like, DNA directed polymerase zeta catalytic subunit
695894
Mouse
MGI:1337131
19714
Rat
RGD:1307087
309812
Dog
REV3 like, DNA directed polymerase zeta catalytic subunit
VGNC:45488
481963
Species
Name
OMA
EggNOG
Inparanoid
Chimp
REV3 like, DNA directed polymerase zeta catalytic subunit
Macaque
REV3 like, DNA directed polymerase zeta catalytic subunit
Mouse
Rat
Dog
REV3 like, DNA directed polymerase zeta catalytic subunit
Publication Statistics
PubMed Score 252.04
PubMed score by year
PubTator Score 65.06
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title