REV3L
DNA polymerase zeta catalytic subunit
Protein Summary
Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
- ENST00000358835
- ENSP00000351697
- ENSG00000009413
- ENST00000368802
- ENSP00000357792
- ENST00000368805
- ENSP00000357795
- ENST00000435970
- ENSP00000402003
- POLZ
- REV3
- POLZ
- REV3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
transcription factor binding site profile | 0.92 | ||
histone modification site profile | 0.84 | ||
virus perturbation | 0.83 | ||
molecular function | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 252.04 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 78 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 252.04 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 78 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (203)
POLD2
Family: Enzyme
Novelty: 0.05932998
p_int: 0.999999995
p_ni: 5e-9
Score: 0.965
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (8)
Reactome (6)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | DNA Damage Bypass | ||||
Reactome | DNA Repair | ||||
Reactome | Translesion synthesis by POLI | ||||
Reactome | Translesion synthesis by POLK | ||||
Reactome | Translesion synthesis by REV1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
DNA Damage Bypass | ||||
DNA Repair | ||||
Translesion synthesis by POLI | ||||
Translesion synthesis by POLK | ||||
Translesion synthesis by REV1 | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (5)
Components (3)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (30)
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 3 | 3 | 2 | 1.1 | 93.9 | ||||
3 | 3 | 0 | 1.3 | 88.1 | |||||
smoking behavior | 1 | 2 | 2 | 87.1 | |||||
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 83.2 | |||||
blood metabolite measurement | 2 | 2 | 2 | 80.7 | |||||
Items per page:
1 – 5 of 30
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 1.1 | 93.9 | ||||
0 | 1.3 | 88.1 | |||||
smoking behavior | 2 | 87.1 | |||||
mean corpuscular hemoglobin concentration | 1 | 83.2 | |||||
blood metabolite measurement | 2 | 80.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | REV3 like, DNA directed polymerase zeta catalytic subunit | VGNC:9601 | 462942 | |||||
Macaque | REV3 like, DNA directed polymerase zeta catalytic subunit | 695894 | ||||||
Mouse | MGI:1337131 | 19714 | ||||||
Rat | RGD:1307087 | 309812 | ||||||
Dog | REV3 like, DNA directed polymerase zeta catalytic subunit | VGNC:45488 | 481963 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | REV3 like, DNA directed polymerase zeta catalytic subunit | |||||
Macaque | REV3 like, DNA directed polymerase zeta catalytic subunit | |||||
Mouse | ||||||
Rat | ||||||
Dog | REV3 like, DNA directed polymerase zeta catalytic subunit | |||||
Publication Statistics
PubMed Score 252.04
PubMed score by year
PubTator Score 65.06
PubTator score by year
Related Publications
Text Mined References (60)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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