Tbio REV3L DNA polymerase zeta catalytic subunit

Protein Summary

Description

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function. The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]

Uniprot Accession IDs

• O60673
• O43214
• Q5TC33

Gene Name

• REV3L

Ensembl ID

• ENST00000358835
• ENSP00000351697
• ENSG00000009413
• ENST00000368802
• ENSP00000357792
• ENST00000368805
• ENSP00000357795
• ENST00000435970
• ENSP00000402003

Symbol

• POLZ
• REV3
• POLZ
• REV3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
transcription factor binding site profile	0.92
histone modification site profile	0.84
virus perturbation	0.83
molecular function	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.49   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 78   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 319.49   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0