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Tchem
RAD1
Cell cycle checkpoint protein RAD1

Protein Summary
Description
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325577
  • ENSP00000313467
  • ENSG00000113456
  • ENST00000341754
  • ENSP00000340879
  • ENST00000382038
  • ENSP00000371469

Symbol
  • REC1
  • REC1
  • HRAD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
virus perturbation
0.9
transcription factor binding site profile
0.82
kinase perturbation
0.71
tissue sample
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.4   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 165.4   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
DIDS
Rendered image for DIDS
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
2
2
89.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
2
89.9
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAD1 checkpoint DNA exonuclease
VGNC:4141
461928
Mouse
MGI:1316678
19355
Rat
RGD:1306496
294800
Dog
RAD1 checkpoint DNA exonuclease
VGNC:45310
479366
Horse
RAD1 checkpoint DNA exonuclease
VGNC:22141
100053946
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAD1 checkpoint DNA exonuclease
Mouse
Rat
Dog
RAD1 checkpoint DNA exonuclease
Horse
RAD1 checkpoint DNA exonuclease
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60671-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
DNA Double-Strand Break Repair
DNA Repair
Protein-Protein Interactions (127)
1 – 10 of 127
HUS1
Tbio
Novelty:  0.00837493
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ZBTB14
Tbio
Family:  TF
Novelty:  0.0245914
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  3e-9
Score:  0.882
Data Source:  BioPlex,STRINGDB
HUS1B
Tdark
Novelty:  0.29267023
p_int:  0.999999972
p_ni:  2.7e-8
p_wrong:  1e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
RAD9A
Tbio
Novelty:  0.00560195
p_int:  0.999999933
p_ni:  2.3e-8
p_wrong:  4.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RFC4
Tbio
Novelty:  0.03232586
p_int:  0.999601989
p_ni:  0.000069714
p_wrong:  0.000328297
Score:  0.967
Data Source:  BioPlex,STRINGDB
ERCC1
Tbio
Novelty:  0.00079472
Score:  0.999
Data Source:  STRINGDB
ATR
Tchem
Family:  Kinase
Novelty:  0.00196978
Score:  0.99
Data Source:  STRINGDB
RAD51B
Tbio
Novelty:  0.00302521
Score:  0.99
Data Source:  STRINGDB
RAD17
Tbio
Novelty:  0.00640979
Score:  0.987
Data Source:  STRINGDB
RAD9B
Tdark
Novelty:  0.38973762
Score:  0.979
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  165.40

PubMed score by year
PubTator Score  125.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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