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Tchem
SLC16A7
Monocarboxylate transporter 2

Protein Summary
Description
Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Functions as high-affinity pyruvate transporter. This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261187
  • ENSP00000261187
  • ENSG00000118596
  • ENST00000547379
  • ENSP00000448071
  • ENST00000552024
  • ENSP00000448742
  • ENST00000552432
  • ENSP00000449547

Symbol
  • MCT2
  • MCT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
gene perturbation
0.76
transcription factor perturbation
0.68
molecular function
0.67
drug
0.6


Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.85   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.85   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
7ACC2
Rendered image for 7ACC2
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
1
2
2
26.1
household income
1
1
1
7.9
waist-hip ratio
1
1
1
1.3
BMI-adjusted waist-hip ratio
1
1
1
0.4
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
26.1
household income
1
7.9
waist-hip ratio
1
1.3
BMI-adjusted waist-hip ratio
1
0.4
1
0.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 16 member 7
VGNC:8536
467047
Macaque
solute carrier family 16 member 7
716540
Mouse
MGI:1330284
20503
Rat
RGD:3691
29735
Dog
solute carrier family 16 member 7
VGNC:46245
481138
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 16 member 7
Macaque
solute carrier family 16 member 7
Mouse
Rat
Dog
solute carrier family 16 member 7
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60669-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Proton-coupled monocarboxylate transport (R-HSA-433692)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Proton-coupled monocarboxylate transport
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Proton-coupled monocarboxylate transport
SLC-mediated transmembrane transport
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Gene Ontology Terms (10)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (39)
1 – 10 of 39
EMB
Tbio
Novelty:  0.00135577
Score:  0.973
Data Source:  Reactome,STRINGDB
BSG
Tbio
Novelty:  0.0010285
Score:  0.819
Data Source:  STRINGDB
SLC17A5
Tbio
Family:  Transporter
Novelty:  0.00678585
Score:  0.718
Data Source:  STRINGDB
SLC5A2
Tclin
Family:  Transporter
Novelty:  0.00066797
Score:  0.682
Data Source:  STRINGDB
SLC2A14
Tbio
Family:  Transporter
Novelty:  0.00247741
Score:  0.678
Data Source:  STRINGDB
SLC2A3
Tchem
Family:  Transporter
Novelty:  0.00229395
Score:  0.678
Data Source:  STRINGDB
ACSS3
Tbio
Family:  Enzyme
Novelty:  0.11246144
Score:  0.641
Data Source:  STRINGDB
SLC2A1
Tchem
Family:  Transporter
Novelty:  0.00027583
Score:  0.638
Data Source:  STRINGDB
PXMP2
Tbio
Novelty:  0.24472872
Score:  0.62
Data Source:  STRINGDB
SLC5A12
Tdark
Family:  Transporter
Novelty:  0.12119749
Score:  0.576
Data Source:  STRINGDB
Publication Statistics
PubMed Score  135.85

PubMed score by year
PubTator Score  61.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer