You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PLIN3
Perilipin-3

Protein Summary
Description
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221957
  • ENSP00000221957
  • ENSG00000105355
  • ENST00000585479
  • ENSP00000465596
  • ENST00000592528
  • ENSP00000467803

Symbol
  • M6PRBP1
  • TIP47
  • PP17
  • TIP47
  • M6PRBP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.98
kinase perturbation
0.96
co-expressed gene
0.91
transcription factor binding site profile
0.81
PubMedID
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.78   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 487   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 104.78   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
perilipin 3
VGNC:12057
455612
Macaque
perilipin 3
696302
Mouse
MGI:1914155
66905
Rat
RGD:1595854
316130
Dog
perilipin 3
VGNC:44692
485031
Species
Name
OMA
EggNOG
Inparanoid
Chimp
perilipin 3
Macaque
perilipin 3
Mouse
Rat
Dog
perilipin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60664-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Chaperone Mediated Autophagy
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Lipophagy
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Autophagy
Chaperone Mediated Autophagy
Intra-Golgi and retrograde Golgi-to-ER traffic
Lipophagy
Membrane Trafficking
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (92)
1 – 10 of 92
PKMYT1
Tchem
Family: Kinase
Novelty: 0.03025516
p_int: 0.999999745
p_ni: 2.51e-7
p_wrong: 4e-9
Score: 0.332
Data Source: BioPlex,STRINGDB
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.99998339
p_ni: 0.00001661
Data Source: BioPlex
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.983873516
p_ni: 0.016126485
Data Source: BioPlex
C16orf58
Tdark
Novelty: 0.34461652
p_int: 0.902345854
p_ni: 0.097654146
Score: 0.161
Data Source: BioPlex,STRINGDB
HCCS
Tbio
Family: Enzyme
Novelty: 0.0022585
p_int: 0.867230111
p_ni: 0.132769887
p_wrong: 2e-9
Score: 0.567
Data Source: BioPlex,STRINGDB
RHOBTB3
Tbio
Novelty: 0.09149494
Score: 0.99
Data Source: STRINGDB
M6PR
Tbio
Novelty: 0.00210407
Score: 0.985
Data Source: STRINGDB
IGF2R
Tchem
Novelty: 0.00138374
Score: 0.984
Data Source: STRINGDB
PGRMC1
Tbio
Novelty: 0.00364386
Score: 0.958
Data Source: STRINGDB
RAB9A
Tbio
Family: Enzyme
Novelty: 0.07006531
Score: 0.954
Data Source: STRINGDB
Publication Statistics
PubMed Score  104.78

PubMed score by year
PubTator Score  75.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer