Protein Summary
Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network. Mannose 6-phophate receptors (MPRs) deliver lysosomal hydrolase from the Golgi to endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2009]
- ENST00000221957
- ENSP00000221957
- ENSG00000105355
- ENST00000585479
- ENSP00000465596
- ENST00000592528
- ENSP00000467803
- M6PRBP1
- TIP47
- PP17
- TIP47
- M6PRBP1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.98 | ||
kinase perturbation | 0.96 | ||
co-expressed gene | 0.91 | ||
transcription factor binding site profile | 0.81 | ||
PubMedID | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.61 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 487 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 116.61 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 487 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0