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Tbio
EXOC3
Exocyst complex component 3

Protein Summary
Description
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315013
  • ENSP00000323377
  • ENSG00000180104
  • ENST00000512944
  • ENSP00000425587

Symbol
  • SEC6
  • SEC6L1
  • SEC6
  • Sec6p
  • SEC6L1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
kinase perturbation
0.96
virus perturbation
0.9
histone modification site profile
0.88
cell type or tissue
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.32   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 118.32   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
EXOC6
Tbio
Novelty:  0.01886811
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
EXOC1
Tbio
Novelty:  0.01073858
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
GCC2
Tbio
Novelty:  0.03809539
p_int:  0.999999996
p_ni:  3e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
TRIP11
Tbio
Novelty:  0.03011344
p_int:  0.999999953
p_ni:  4e-9
p_wrong:  4.2e-8
Score:  0.279
Data Source:  BioPlex,STRINGDB
EXOC2
Tbio
Novelty:  0.01434464
p_int:  0.999999669
p_ni:  3.31e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
SCLT1
Tbio
Novelty:  0.10969171
p_int:  0.999999066
p_ni:  9.05e-7
p_wrong:  2.9e-8
Score:  0.67
Data Source:  BioPlex,STRINGDB
EXOC6B
Tbio
Novelty:  0.11301293
p_int:  0.999998908
p_ni:  0.000001092
Score:  0.986
Data Source:  BioPlex,STRINGDB
KIZ
Tbio
Novelty:  0.0644373
p_int:  0.99999788
p_ni:  0.000002117
p_wrong:  3e-9
Score:  0.669
Data Source:  BioPlex,STRINGDB
DTNBP1
Tbio
Novelty:  0.00341619
p_int:  0.999997425
p_ni:  0.000002572
p_wrong:  3e-9
Score:  0.574
Data Source:  BioPlex,STRINGDB
EXOC8
Tbio
Novelty:  0.03090842
p_int:  0.999993332
p_ni:  0.000006668
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Cargo trafficking to the periciliary membrane (R-HSA-5620920)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Cilium Assembly
Reactome
Insulin processing
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Cargo trafficking to the periciliary membrane
Cilium Assembly
Insulin processing
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
3
2
6.3
87.7
hemoglobin measurement
4
3
4
79.8
hematocrit
2
1
2
66.7
red blood cell density measurement
1
1
1
58.3
lung disease associated with cystic fibrosis
1
1
1
54.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
2
6.3
87.7
hemoglobin measurement
4
79.8
hematocrit
2
66.7
red blood cell density measurement
1
58.3
lung disease associated with cystic fibrosis
1
54.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 3
VGNC:11944
104001061
Macaque
exocyst complex component 3
708422
Mouse
MGI:2443972
211446
Rat
RGD:621790
252881
Dog
exocyst complex component 3
478633
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exocyst complex component 3
Macaque
exocyst complex component 3
Mouse
Rat
Dog
exocyst complex component 3
Publication Statistics
PubMed Score 118.32
PubMed score by year
PubTator Score 40.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title