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Tbio
TSPAN3
Tetraspanin-3

Protein Summary
Description
Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair. The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000267970
  • ENSP00000267970
  • ENSG00000140391
  • ENST00000346495
  • ENSP00000341329
  • ENST00000424443
  • ENSP00000407243

Symbol
  • TM4SF8
  • TM4-A
  • TM4SF8
  • TSPAN-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.9
transcription factor perturbation
0.88
microRNA
0.8
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.09   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.09   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (78)
1 – 10 of 78
CC2D1A
Tbio
Novelty:  0.01970021
p_int:  0.999997388
p_ni:  0.000002611
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.999975832
p_ni:  0.000024164
p_wrong:  4e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
UGCG
Tclin
Family:  Enzyme
Novelty:  0.00481791
p_int:  0.999551637
p_ni:  0.000322717
p_wrong:  0.000125647
Score:  0.523
Data Source:  BioPlex,STRINGDB
LRRC8B
Tbio
Novelty:  0.16457267
p_int:  0.998404003
p_ni:  0.001588558
p_wrong:  0.000007439
Data Source:  BioPlex
RDH14
Tdark
Family:  Enzyme
Novelty:  0.35816611
p_int:  0.998135042
p_ni:  0.000721267
p_wrong:  0.00114369
Score:  0.227
Data Source:  BioPlex,STRINGDB
EPHA5
Tchem
Family:  Kinase
Novelty:  0.01143252
p_int:  0.99769917
p_ni:  3.56e-7
p_wrong:  0.002300474
Score:  0.77
Data Source:  BioPlex,STRINGDB
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.99734318
p_ni:  0.002655987
p_wrong:  8.33e-7
Data Source:  BioPlex
TSPAN2
Tbio
Novelty:  0.03842973
p_int:  0.997320959
p_ni:  0.002678216
p_wrong:  8.25e-7
Score:  0.23
Data Source:  BioPlex,STRINGDB
FGFR2
Tclin
Family:  Kinase
Novelty:  0.00066613
p_int:  0.997161407
p_ni:  0.002838582
p_wrong:  1.1e-8
Score:  0.207
Data Source:  BioPlex,STRINGDB
FAM189B
Tbio
Novelty:  0.21064304
p_int:  0.996924295
p_ni:  0.002952444
p_wrong:  0.000123261
Data Source:  BioPlex
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
72.4
BMI-adjusted hip circumference
2
4
5
65.3
myeloid white cell count
1
1
1
59.9
self reported educational attainment
1
1
1
42.3
leukocyte count
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
72.4
BMI-adjusted hip circumference
5
65.3
myeloid white cell count
1
59.9
self reported educational attainment
1
42.3
leukocyte count
1
30.2
Find similar targets by:
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 3
467832
Macaque
tetraspanin 3
708428
Mouse
MGI:1928098
56434
Rat
RGD:1359444
300733
Dog
tetraspanin 3
VGNC:47919
487663
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tetraspanin 3
Macaque
tetraspanin 3
Mouse
Rat
Dog
tetraspanin 3
Publication Statistics
PubMed Score 16.09
PubMed score by year
PubTator Score 4.19
PubTator score by year