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Tbio
DIAPH1
Protein diaphanous homolog 1

Protein Summary
Description
Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers (By similarity). Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization (By similarity). Required for cytokinesis, and transcriptional activation of the serum response factor (By similarity). DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics (By similarity). Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity. Acts in a Rho-dependent manner to recruit PFY1 to the membrane (By similarity). In hear cells, it may play a role in the regulation of actin polymerization in hair cells (PubMed:20937854, PubMed:21834987, PubMed:26912466). The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389054
  • ENSP00000373706
  • ENSG00000131504
  • ENST00000518047
  • ENSP00000428268

Symbol
  • DIAP1
  • DIA1
  • DRF1
  • DFNA1
  • LFHL1
  • SCBMS
  • hDIA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
interacting protein
0.99
protein domain
0.99
virus perturbation
0.98
transcription factor binding site profile
0.97


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.2   (req: < 5)
Gene RIFs: 62   (req: <= 3)
Antibodies: 333   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.2   (req: >= 5)
Gene RIFs: 62   (req: > 3)
Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
72.4
mathematical ability
1
1
1
52
1
1
0
1
41.9
triglyceride measurement
1
1
1
28.1
mean platelet volume
2
2
2
27.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
72.4
mathematical ability
1
52
0
1
41.9
triglyceride measurement
1
28.1
mean platelet volume
2
27.6
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
diaphanous related formin 1
700918
Mouse
MGI:1194490
13367
Rat
RGD:1310707
307483
Dog
diaphanous related formin 1
VGNC:39955
100684883
Horse
diaphanous related formin 1
VGNC:17183
100072186
Species
Name
OMA
EggNOG
Inparanoid
Macaque
diaphanous related formin 1
Mouse
Rat
Dog
diaphanous related formin 1
Horse
diaphanous related formin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60610-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
ERBB2 Regulates Cell Motility (R-HSA-6785631)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ERBB2 Regulates Cell Motility
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
RHO GTPase Effectors
Name
Explore in Pharos
Explore in Source
ERBB2 Regulates Cell Motility
Immune System
Innate Immune System
Neutrophil degranulation
RHO GTPase Effectors
Gene Ontology Terms (27)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (123)
1 – 10 of 123
SOWAHB
Tdark
Novelty: 1.09724527
p_int: 0.999994206
p_ni: 0.000005794
Data Source: BioPlex
DCAF7
Tbio
Novelty: 0.02609518
p_int: 0.999991772
p_ni: 0.000008228
Score: 0.379
Data Source: BioPlex,STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
p_int: 0.997557845
p_ni: 0.002442154
p_wrong: 1e-9
Score: 0.897
Data Source: BioPlex,STRINGDB
PFN2
Tbio
Novelty: 0.00605366
p_int: 0.992734706
p_ni: 0.007265294
p_wrong: 1e-9
Score: 0.943
Data Source: BioPlex,STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
p_int: 0.794447261
p_ni: 0.205552739
Score: 0.672
Data Source: BioPlex,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.989
Data Source: Reactome,STRINGDB
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.981
Data Source: STRINGDB
RHOB
Tbio
Family: Enzyme
Novelty: 0.0019205
Score: 0.969
Data Source: Reactome,STRINGDB
IQGAP1
Tbio
Family: Enzyme
Novelty: 0.00434481
Score: 0.963
Data Source: STRINGDB
PFN1
Tbio
Novelty: 0.0048861
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  66.20

PubMed score by year
PubTator Score  68.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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