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Tbio
GFRA3
GDNF family receptor alpha-3

Protein Summary
Description
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274721
  • ENSP00000274721
  • ENSG00000146013
  • ENST00000378362
  • ENSP00000367613

Symbol
  • GDNFR3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.66
cell line
0.65
disease perturbation
0.62
PubMedID
0.6
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 289   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.33   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.989491989
p_ni:  0.010430423
p_wrong:  0.000077588
Data Source:  BioPlex
CNNM1
Tdark
Novelty:  0.11053515
p_int:  0.984091514
p_ni:  0.01590789
p_wrong:  5.96e-7
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.899487231
p_ni:  0.100512769
Data Source:  BioPlex
ADAMTS2
Tbio
Family:  Enzyme
Novelty:  0.00852208
p_int:  0.824768194
p_ni:  0.013053179
p_wrong:  0.162178627
Data Source:  BioPlex
B3GALNT2
Tbio
Family:  Enzyme
Novelty:  0.08266178
p_int:  0.818285543
p_ni:  0.181519436
p_wrong:  0.000195021
Data Source:  BioPlex
SLC12A7
Tbio
Family:  Transporter
Novelty:  0.02248904
p_int:  0.81702716
p_ni:  0.128514798
p_wrong:  0.054458042
Data Source:  BioPlex
TM2D3
Tbio
Novelty:  0.09408834
p_int:  0.772519313
p_ni:  0.227414787
p_wrong:  0.0000659
Data Source:  BioPlex
ARTN
Tbio
Novelty:  0.00799442
Score:  0.988
Data Source:  Reactome,STRINGDB
PSPN
Tbio
Novelty:  0.02169895
Score:  0.973
Data Source:  Reactome,STRINGDB
NRTN
Tbio
Novelty:  0.00547984
Score:  0.968
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
FLT3 Signaling
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
73.3
self reported educational attainment
1
1
1
30.2
mathematical ability
1
1
1
30.2
2
1
0
1.1
24.5
age at menarche
1
1
0
2.4
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
73.3
self reported educational attainment
1
30.2
mathematical ability
1
30.2
0
1.1
24.5
age at menarche
0
2.4
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GDNF family receptor alpha 3
VGNC:4012
462093
Macaque
GDNF family receptor alpha 3
714050
Mouse
MGI:1201403
14587
Rat
RGD:620502
84422
Dog
GDNF family receptor alpha 3
VGNC:41191
481527
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GDNF family receptor alpha 3
Macaque
GDNF family receptor alpha 3
Mouse
Rat
Dog
GDNF family receptor alpha 3
Publication Statistics
PubMed Score 7.33
PubMed score by year
PubTator Score 24.08
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title