Tbio GFRA3 GDNF family receptor alpha-3

Protein Summary

Description

Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60609
• B2RA36
• B4DMY9
• Q6UW20
• Q8IUZ2
• GDNF receptor alpha-3

Gene Name

• GFRA3

Ensembl ID

• ENST00000274721
• ENSP00000274721
• ENSG00000146013
• ENST00000378362
• ENSP00000367613

Symbol

• GDNFR3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.66
cell line	0.65
disease perturbation	0.62
PubMedID	0.6
cell type or tissue	0.57

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.93   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 289   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.93   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0