Tchem TLR5 Toll-like receptor 5

Protein Summary

Description

Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]

Uniprot Accession IDs

• O60602
• B1AZ05
• B3Y633
• B9VJ63
• D1CS80
• D3DTB8
• O15456
• Q32MI2
• Q32MI3

Gene Name

• TLR5

Ensembl ID

• ENST00000366881
• ENSP00000355846
• ENSG00000187554
• ENST00000540964
• ENSP00000440643

Symbol

• TIL3
• SLE1
• TIL3
• SLEB1
• MELIOS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.81
biological process	0.79
phenotype	0.77
tissue sample	0.74
disease	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1159.42   (req: < 5)

Gene RIFs: 200   (req: <= 3)

Antibodies: 873   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1159.42   (req: >= 5)

Gene RIFs: 200   (req: > 3)

Antibodies: 873   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0