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Tbio
TLR5
Toll-like receptor 5

Protein Summary
Description
Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366881
  • ENSP00000355846
  • ENSG00000187554
  • ENST00000540964
  • ENSP00000440643

Symbol
  • TIL3
  • SLE1
  • TIL3
  • SLEB1
  • MELIOS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
biological process
0.79
phenotype
0.77
tissue sample
0.74
disease
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 929.92   (req: < 5)
Gene RIFs: 161   (req: <= 3)
Antibodies: 873   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 929.92   (req: >= 5)
Gene RIFs: 161   (req: > 3)
Antibodies: 873   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
1
30.2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (64)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases associated with the TLR signaling cascade
Reactome
Diseases of Immune System
Reactome
IRAK4 deficiency (TLR5)
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Disease
Diseases associated with the TLR signaling cascade
Diseases of Immune System
IRAK4 deficiency (TLR5)
Immune System
Protein-Protein Interactions (291)
1 – 10 of 291
DHRS3
Tbio
Family: Enzyme
Novelty: 0.04448013
p_int: 0.999786986
p_ni: 0.000092193
p_wrong: 0.000120821
Score: 0.249
Data Source: BioPlex,STRINGDB
PTRH2
Tbio
Family: Enzyme
Novelty: 0.02494576
p_int: 0.999235339
p_ni: 0.000764661
Data Source: BioPlex
CNPY3
Tbio
Novelty: 0.11473132
p_int: 0.984147686
p_ni: 0.015852314
Score: 0.672
Data Source: BioPlex,STRINGDB
ACOT12
Tbio
Family: Enzyme
Novelty: 0.04464523
p_int: 0.966722071
p_ni: 0.000002559
p_wrong: 0.03327537
Score: 0.219
Data Source: BioPlex,STRINGDB
SNX14
Tbio
Novelty: 0.10690692
p_int: 0.965554715
p_ni: 0.034321638
p_wrong: 0.000123646
Score: 0.188
Data Source: BioPlex,STRINGDB
PRXL2A
Tchem
Novelty: 0.01336664
p_int: 0.945744261
p_ni: 0.054255739
Score: 0.211
Data Source: BioPlex,STRINGDB
DHRS7
Tbio
Family: Enzyme
Novelty: 0.16713756
p_int: 0.908594814
p_ni: 0.091405186
Data Source: BioPlex
DDRGK1
Tbio
Novelty: 0.10774064
p_int: 0.872609916
p_ni: 0.127390084
Data Source: BioPlex
TMX2
Tbio
Novelty: 0.09856355
p_int: 0.7966664
p_ni: 0.203297024
p_wrong: 0.000036576
Score: 0.169
Data Source: BioPlex,STRINGDB
CTDNEP1
Tbio
Family: Enzyme
Novelty: 0.09348082
p_int: 0.794571273
p_ni: 0.205428727
Score: 0.157
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  929.92

PubMed score by year
PubTator Score  382.11

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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