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Tbio
CCNT2
Cyclin-T2

Protein Summary
Description
Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFB), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II) (PubMed:9499409, PubMed:15563843). The activity of this complex is regulated by binding with 7SK snRNA (PubMed:11713533). Plays a role during muscle differentiation; P-TEFB complex interacts with MYOD1; this tripartite complex promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation and binds the chromatin of promoters and enhancers of muscle-specific genes; this event correlates with hyperphosphorylation of the CTD domain of RNA pol II (By similarity). In addition, enhances MYOD1-dependent transcription through interaction with PKN1 (PubMed:16331689). Involved in early embryo development (By similarity). (Microbial infectio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264157
  • ENSP00000264157
  • ENSG00000082258
  • ENST00000295238
  • ENSP00000295238

Symbol
  • CYCT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.95
pathway
0.91
drug perturbation
0.87
histone modification site profile
0.84
transcription factor perturbation
0.84


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.54   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.54   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin T2
VGNC:10652
470546
Macaque
cyclin T2
708813
Mouse
MGI:1920199
72949
Rat
RGD:1309205
304758
Dog
cyclin T2
VGNC:38907
476126
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin T2
Macaque
cyclin T2
Mouse
Rat
Dog
cyclin T2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (24)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of RNA Pol II elongation complex
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of RNA Pol II elongation complex
Gene expression (Transcription)
Generic Transcription Pathway
Gene Ontology Terms (27)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (185)
1 – 10 of 185
HEXIM1
Tbio
Novelty: 0.0142443
p_int: 0.999999864
p_ni: 1.36e-7
Score: 0.968
Data Source: BioPlex,STRINGDB
CDK9
Tchem
Family: Kinase
Novelty: 0.00210218
p_int: 0.99999954
p_ni: 4.6e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
HEXIM2
Tbio
Novelty: 0.14814693
p_int: 0.999991027
p_ni: 0.000008973
Score: 0.888
Data Source: BioPlex,STRINGDB
AFF4
Tbio
Family: TF
Novelty: 0.02113896
p_int: 0.999987486
p_ni: 0.000012514
Score: 0.996
Data Source: BioPlex,STRINGDB
CDK6
Tclin
Family: Kinase
Novelty: 0.00109319
p_int: 0.999964278
p_ni: 0.000035722
Score: 0.856
Data Source: BioPlex,STRINGDB
ELL3
Tbio
Family: Enzyme
Novelty: 0.18245631
p_int: 0.999948753
p_ni: 0.000051243
p_wrong: 3e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
H2AFY2
Tbio
Novelty: 0.09948698
p_int: 0.860734839
p_ni: 0.13874898
p_wrong: 0.000516181
Score: 0.177
Data Source: BioPlex,STRINGDB
CDK12
Tchem
Family: Kinase
Novelty: 0.0119925
Score: 0.977
Data Source: STRINGDB
CDK7
Tchem
Family: Kinase
Novelty: 0.00322814
Score: 0.972
Data Source: STRINGDB
POLR2A
Tbio
Family: Enzyme
Novelty: 0.00188323
Score: 0.971
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.54

PubMed score by year
PubTator Score  16.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer