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Tbio
EIF4E2
Eukaryotic translation initiation factor 4E type 2

Protein Summary
Description
Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258416
  • ENSP00000258416
  • ENSG00000135930
  • ENST00000409098
  • ENSP00000386996

Symbol
  • EIF4EL3
  • 4EHP
  • IF4e
  • 4E-LP
  • h4EHP
  • EIF4EL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
transcription factor binding site profile
0.9
histone modification site profile
0.88
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.04   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.04   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
73.1
lymphocyte count
1
1
1
47.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
73.1
lymphocyte count
1
47.5
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E family member 2
VGNC:370
460015
Macaque
eukaryotic translation initiation factor 4E family member 2
713487
Mouse
MGI:1914440
26987
Rat
RGD:1307790
363275
Dog
eukaryotic translation initiation factor 4E family member 2
610238
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eukaryotic translation initiation factor 4E family member 2
Macaque
eukaryotic translation initiation factor 4E family member 2
Mouse
Rat
Dog
eukaryotic translation initiation factor 4E family member 2
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60573-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
ISG15 antiviral mechanism
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
ISG15 antiviral mechanism
Immune System
Interferon Signaling
Gene Ontology Terms (9)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (128)
1 – 10 of 128
GIGYF1
Tdark
Novelty: 0.33031107
p_int: 1
Score: 0.994
Data Source: BioPlex,STRINGDB
GIGYF2
Tchem
Novelty: 0.02395014
p_int: 0.99999999
p_ni: 1e-8
Score: 0.997
Data Source: BioPlex,STRINGDB
EIF4ENIF1
Tbio
Novelty: 0.03835664
p_int: 0.999999955
p_ni: 2.1e-8
p_wrong: 2.4e-8
Score: 0.965
Data Source: BioPlex,STRINGDB
EIF4EBP2
Tbio
Novelty: 0.01926413
p_int: 0.999999289
p_ni: 7.09e-7
p_wrong: 1e-9
Score: 0.604
Data Source: BioPlex,STRINGDB
EIF4EBP3
Tbio
Novelty: 0.12272754
p_int: 0.999927997
p_ni: 0.000072003
Score: 0.573
Data Source: BioPlex,STRINGDB
WDR83
Tbio
Novelty: 0.11602568
p_int: 0.995935943
p_ni: 0.004064057
Data Source: BioPlex
EIF4EBP1
Tbio
Novelty: 0.00098313
p_int: 0.99117197
p_ni: 0.008691013
p_wrong: 0.000137017
Score: 0.989
Data Source: BioPlex,STRINGDB
PIP
Tbio
Novelty: 0.00208509
p_int: 0.980734786
p_ni: 0.019265167
p_wrong: 4.7e-8
Data Source: BioPlex
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.936235062
p_ni: 0.063764744
p_wrong: 1.94e-7
Score: 0.181
Data Source: BioPlex,STRINGDB
C10orf88
Tdark
Novelty: 0.49807003
p_int: 0.936068044
p_ni: 0.063931622
p_wrong: 3.34e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  20.04

PubMed score by year
PubTator Score  13.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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