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Tbio
PLOD3
Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3

Protein Classes
Protein Summary
Description
Multifunctional enzyme that catalyzes a series of essential post-translational modifications on Lys residues in procollagen (PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Plays a redundant role in catalyzing the formation of hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:9582318, PubMed:9724729, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Plays a redundant role in catalyzing the transfer of galactose onto hydroxylysine groups, giving rise to galactosyl 5-hydroxylysine (PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Has an essential role by catalyzing the subsequent transfer of glucose moieties, giving rise to 1,2-glucosylgalactosyl-5-hydroxylysine residues (PubMed:10934207, PubMed:11896059, PubMed:11956192, PubMed:12475640, PubMed:18298658, PubMed:30089812, PubMed:18834968). Catalyzes hydroxylation and glycosylation of Lys residues in the MBL1 collagen-like do ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000223127
  • ENSP00000223127
  • ENSG00000106397

Symbol
  • LH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.98
molecular function
0.95
kinase perturbation
0.93
histone modification site profile
0.91
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.84   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.84   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Collagen biosynthesis and modifying enzymes (R-HSA-1650814)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Collagen biosynthesis and modifying enzymes
Collagen formation
Extracellular matrix organization
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (122)
1 – 10 of 122
VIPAS39
Tbio
Novelty: 0.03489628
p_int: 0.999999949
p_ni: 5.1e-8
Score: 0.346
Data Source: BioPlex,STRINGDB
VPS33B
Tbio
Novelty: 0.02516107
p_int: 0.999999911
p_ni: 8.9e-8
Score: 0.266
Data Source: BioPlex,STRINGDB
PRRC2B
Tdark
Novelty: 0.51051051
p_int: 0.999992098
p_ni: 0.000007902
Data Source: BioPlex
COL4A6
Tbio
Novelty: 0.03225517
p_int: 0.999941407
p_ni: 0.000002133
p_wrong: 0.000056459
Score: 0.92
Data Source: BioPlex,STRINGDB
COL4A2
Tbio
Novelty: 0.0117791
p_int: 0.999940229
p_ni: 0.000059771
Score: 0.934
Data Source: BioPlex,STRINGDB
GEN1
Tbio
Family: Enzyme
Novelty: 0.00144747
p_int: 0.999840199
p_ni: 2.6e-8
p_wrong: 0.000159775
Data Source: BioPlex
FLYWCH1
Tdark
Novelty: 0.42253521
p_int: 0.999840199
p_ni: 2.6e-8
p_wrong: 0.000159775
Data Source: BioPlex
COL4A1
Tbio
Novelty: 0.00485546
p_int: 0.999780963
p_ni: 0.000050282
p_wrong: 0.000168755
Score: 0.938
Data Source: BioPlex,STRINGDB
CNKSR3
Tbio
Family: Enzyme
Novelty: 0.28155853
p_int: 0.999588283
p_ni: 0.000247199
p_wrong: 0.000164518
Data Source: BioPlex
COL18A1
Tbio
Novelty: 0.00063031
p_int: 0.999048948
p_ni: 0.000951052
Score: 0.905
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  33.84

PubMed score by year
PubTator Score  45.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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