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Tbio
BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Protein Summary
Description
Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287598
  • ENSP00000287598
  • ENSG00000156970
  • ENST00000412359
  • ENSP00000398470

Symbol
  • BUBR1
  • MAD3L
  • SSK1
  • MVA1
  • SSK1
  • BUBR1
  • Bub1A
  • MAD3L
  • hBUBR1
  • BUB1beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
hub protein
0.92
interacting protein
0.91
molecular function
0.91
co-expressed gene
0.87


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.36   (req: < 5)
Gene RIFs: 107   (req: <= 3)
Antibodies: 638   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 436.36   (req: >= 5)
Gene RIFs: 107   (req: > 3)
Antibodies: 638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1333889
12236
Rat
RGD:619791
171576
Dog
BUB1 mitotic checkpoint serine/threonine kinase B
VGNC:38566
608350
Horse
BUB1 mitotic checkpoint serine/threonine kinase B
VGNC:15925
100629735
Cow
BUB1 mitotic checkpoint serine/threonine kinase B
VGNC:26605
537027
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
BUB1 mitotic checkpoint serine/threonine kinase B
Horse
BUB1 mitotic checkpoint serine/threonine kinase B
Cow
BUB1 mitotic checkpoint serine/threonine kinase B
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60566-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (120)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Gene Ontology Terms (24)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (488)
1 – 10 of 488
BUB3
Tbio
Novelty: 0.00714143
p_int: 0.999999977
p_ni: 1.1e-8
p_wrong: 1.2e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
CDC20
Tbio
Novelty: 0.00197887
p_int: 0.999999005
p_ni: 9.95e-7
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BUB1
Tchem
Family: Kinase
Novelty: 0.00327514
p_int: 0.999981491
p_ni: 0.000018509
Score: 0.999
Data Source: BioPlex,STRINGDB
ANAPC5
Tbio
Family: Enzyme
Novelty: 0.02102572
p_int: 0.997706667
p_ni: 0.002293312
p_wrong: 2.1e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
SEMA4C
Tbio
Novelty: 0.01237067
p_int: 0.988179287
p_ni: 0.011080255
p_wrong: 0.000740459
Data Source: BioPlex
RAE1
Tbio
Novelty: 0.01342883
p_int: 0.982956642
p_ni: 0.017043358
Score: 0.954
Data Source: BioPlex,STRINGDB
TYW3
Tdark
Novelty: 0.15183348
p_int: 0.867080583
p_ni: 0.131659463
p_wrong: 0.001259954
Score: 0.161
Data Source: BioPlex,STRINGDB
ZWINT
Tbio
Novelty: 0.02153276
Score: 0.999
Data Source: STRINGDB
ANAPC7
Tbio
Family: Enzyme
Novelty: 0.17956785
Score: 0.999
Data Source: STRINGDB
ANAPC1
Tbio
Family: Enzyme
Novelty: 0.0521845
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  436.36

PubMed score by year
PubTator Score  288.69

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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