NMT2
Glycylpeptide N-tetradecanoyltransferase 2
Protein Summary
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
- ENST00000378165
- ENSP00000367407
- ENSG00000152465
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
kinase perturbation | 0.88 | ||
histone modification site profile | 0.85 | ||
transcription factor binding site profile | 0.78 | ||
microRNA | 0.77 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.79 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 360 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 22.79 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 360 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 7
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0