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Tchem
NMT2
Glycylpeptide N-tetradecanoyltransferase 2

Protein Summary
Description
Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins. This gene encodes one of two N-myristoyltransferase proteins. N-terminal myristoylation is a lipid modification that is involved in regulating the function and localization of signaling proteins. The encoded protein catalyzes the addition of a myristoyl group to the N-terminal glycine residue of many signaling proteins, including the human immunodeficiency virus type 1 (HIV-1) proteins, Gag and Nef. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378165
  • ENSP00000367407
  • ENSG00000152465
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.88
histone modification site profile
0.85
transcription factor binding site profile
0.78
microRNA
0.77


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.74   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 360   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.74   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (73)
CHURC1
Tbio
Novelty:  0.05885372
p_int:  0.999998282
p_ni:  0.000001718
Data Source:  BioPlex
GPRC5C
Tbio
Family:  GPCR
Novelty:  0.16942353
p_int:  0.999997128
p_ni:  0.000002869
p_wrong:  3e-9
Data Source:  BioPlex
ASB6
Tdark
Novelty:  0.32074223
p_int:  0.999992043
p_ni:  0.000007956
p_wrong:  1e-9
Data Source:  BioPlex
NCS1
Tbio
Novelty:  0.0051468
p_int:  0.999982997
p_ni:  0.000017003
Score:  0.181
Data Source:  BioPlex,STRINGDB
MARCKSL1
Tbio
Novelty:  0.01290798
p_int:  0.999898742
p_ni:  0.000101248
p_wrong:  1e-8
Data Source:  BioPlex
ODF3L2
Tdark
Novelty:  1.4355239
p_int:  0.999539348
p_ni:  0.000460652
Score:  0.204
Data Source:  BioPlex,STRINGDB
ANGPTL4
Tbio
Novelty:  0.00237867
p_int:  0.999382286
p_ni:  0.000617714
Score:  0.173
Data Source:  BioPlex,STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
p_int:  0.999345636
p_ni:  0.000654325
p_wrong:  4e-8
Score:  0.183
Data Source:  BioPlex,STRINGDB
FAM84B
Tbio
Novelty:  0.10702561
p_int:  0.998824061
p_ni:  0.001175904
p_wrong:  3.5e-8
Score:  0.239
Data Source:  BioPlex,STRINGDB
AIFM3
Tbio
Novelty:  0.07970284
p_int:  0.998795814
p_ni:  0.001204184
p_wrong:  2e-9
Score:  0.468
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Assembly Of The HIV Virion (R-HSA-175474)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly Of The HIV Virion
Reactome
Disease
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
HIV Infection
Name
Explore in Pharos
Explore in Source
Assembly Of The HIV Virion
Disease
G alpha (i) signalling events
GPCR downstream signalling
HIV Infection
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
1
1
0.4
1
1
0
1.2
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hip circumference
1
0.4
0
1.2
0.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-myristoyltransferase 2
VGNC:4965
450321
Macaque
N-myristoyltransferase 2
703394
Mouse
MGI:1202298
18108
Rat
RGD:1303175
291318
Dog
N-myristoyltransferase 2
VGNC:52219
487120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-myristoyltransferase 2
Macaque
N-myristoyltransferase 2
Mouse
Rat
Dog
N-myristoyltransferase 2
Publication Statistics
PubMed Score 16.74
PubMed score by year
PubTator Score 12.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title