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Tbio
CIDEA
Cell death activator CIDE-A

Protein Summary
Description
Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear. This gene encodes the homolog of the mouse protein Cidea that has been shown to activate apoptosis. This activa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000320477
  • ENSP00000320209
  • ENSG00000176194

Symbol
  • CIDE-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.88
gene perturbation
0.85
PubMedID
0.72
cell line
0.56
disease perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.48   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 279   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.48   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 279   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
ICAM1
Tchem
Novelty:  0.00009746
p_int:  0.973565628
p_ni:  0.026431942
p_wrong:  0.00000243
Score:  0.169
Data Source:  BioPlex,STRINGDB
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.972991433
p_ni:  0.027007405
p_wrong:  0.000001162
Score:  0.269
Data Source:  BioPlex,STRINGDB
IGHG2
Tclin
p_int:  0.901602167
p_ni:  0.097798046
p_wrong:  0.000599787
Data Source:  BioPlex
KPRP
Tdark
Novelty:  0.11744927
p_int:  0.81163983
p_ni:  0.188082748
p_wrong:  0.000277422
Score:  0.187
Data Source:  BioPlex,STRINGDB
PKP1
Tbio
Novelty:  0.0100609
p_int:  0.764375886
p_ni:  0.235624114
Score:  0.326
Data Source:  BioPlex,STRINGDB
CIDEC
Tbio
Novelty:  0.01081754
Score:  0.952
Data Source:  Reactome,STRINGDB
UCP1
Tbio
Novelty:  0.00055954
Score:  0.925
Data Source:  STRINGDB
PRDM16
Tbio
Family:  TF; Epigenetic
Novelty:  0.00261891
Score:  0.859
Data Source:  STRINGDB
DFFB
Tbio
Novelty:  0.00475349
Score:  0.856
Data Source:  STRINGDB
COX7A1
Tbio
Family:  Enzyme
Novelty:  0.02514171
Score:  0.792
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Lipid particle organization (R-HSA-8964572)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Lipid particle organization
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Lipid particle organization
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1270845
12683
Rat
RGD:1305106
291541
Dog
cell death-inducing DFFA-like effector a
VGNC:39271
490559
Horse
cell death-inducing DFFA-like effector a [Source:HGNC Symbol;Acc:HGNC:1976]
Pig
cell death-inducing DFFA-like effector a
100127171
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cell death-inducing DFFA-like effector a
Horse
cell death-inducing DFFA-like effector a [Source:HGNC Symbol;Acc:HGNC:1976]
Pig
cell death-inducing DFFA-like effector a
Publication Statistics
PubMed Score 100.48
PubMed score by year
PubTator Score 40.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title