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Tdark
TDRD6
Tudor domain-containing protein 6

Protein Summary
Description
Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression. This gene encodes a tudor domain-containing protein and component of the chromatoid body, a type of ribonucleoprotein granule present in male germ cells. Studies in rodents have demonstrated a role for the encoded protein in spermiogenesis and the nonsense mediated decay (NMD) pathway. This protein is a major autoantigen in human patients with autoimmune polyendocrine syndrome type 1 (APS1). [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316081
  • ENSP00000346065
  • ENSG00000180113
  • ENST00000544460
  • ENSP00000443299

Symbol
  • TDR2
  • CT41.2
  • SPATA36
  • NY-CO-45
  • bA446F17.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.66
cellular component
0.61
PubMedID
0.6
tissue sample
0.6
cell line
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.71   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.71   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
4
4
3
41.9
98.6
lipoprotein-associated phospholipase A(2) change measurement
1
1
1
83.5
response to darapladib
1
1
1
83.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
3
41.9
98.6
lipoprotein-associated phospholipase A(2) change measurement
1
83.5
response to darapladib
1
83.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tudor domain containing 6
VGNC:3746
472020
Macaque
tudor domain containing 6
704453
Mouse
MGI:2679727
210510
Rat
RGD:1305956
316254
Dog
tudor domain containing 6
VGNC:47224
474925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tudor domain containing 6
Macaque
tudor domain containing 6
Mouse
Rat
Dog
tudor domain containing 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60522-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Gene Silencing by RNA (R-HSA-211000)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene Silencing by RNA
Reactome
Gene expression (Transcription)
Reactome
PIWI-interacting RNA (piRNA) biogenesis
Name
Explore in Pharos
Explore in Source
Gene Silencing by RNA
Gene expression (Transcription)
PIWI-interacting RNA (piRNA) biogenesis
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
PIWIL1
Tbio
Novelty:  0.00095911
Score:  0.987
Data Source:  Reactome,STRINGDB
PIWIL2
Tbio
Novelty:  0.00907402
Score:  0.966
Data Source:  STRINGDB
HENMT1
Tdark
Family:  Enzyme
Novelty:  0.17427834
Score:  0.952
Data Source:  Reactome,STRINGDB
TDRKH
Tbio
Family:  Epigenetic
Novelty:  0.0875409
Score:  0.944
Data Source:  Reactome,STRINGDB
DDX25
Tbio
Family:  Enzyme
Novelty:  0.04593291
Score:  0.873
Data Source:  STRINGDB
MAEL
Tbio
Novelty:  0.01925239
Score:  0.848
Data Source:  STRINGDB
TDRD7
Tbio
Family:  Epigenetic
Novelty:  0.03580848
Score:  0.84
Data Source:  STRINGDB
TDRD5
Tdark
Family:  Epigenetic
Novelty:  0.115495
Score:  0.836
Data Source:  STRINGDB
TDRD12
Tdark
Family:  Epigenetic
Novelty:  0.2276017
Score:  0.823
Data Source:  STRINGDB
PIWIL4
Tbio
Novelty:  0.00105088
Score:  0.794
Data Source:  STRINGDB
Publication Statistics
PubMed Score  14.71

PubMed score by year
PubTator Score  9.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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