TDRD6
Tudor domain-containing protein 6
Protein Summary
Involved in spermiogenesis, chromatoid body formation and for proper precursor and mature miRNA expression. This gene encodes a tudor domain-containing protein and component of the chromatoid body, a type of ribonucleoprotein granule present in male germ cells. Studies in rodents have demonstrated a role for the encoded protein in spermiogenesis and the nonsense mediated decay (NMD) pathway. This protein is a major autoantigen in human patients with autoimmune polyendocrine syndrome type 1 (APS1). [provided by RefSeq, Oct 2016]
- ENST00000316081
- ENSP00000346065
- ENSG00000180113
- ENST00000544460
- ENSP00000443299
- TDR2
- CT41.2
- SPATA36
- NY-CO-45
- bA446F17.4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.66 | ||
cellular component | 0.61 | ||
PubMedID | 0.6 | ||
tissue sample | 0.6 | ||
cell line | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.44 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 9 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 18.44 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 9 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0