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Tbio
B4GALT4
Beta-1,4-galactosyltransferase 4

Protein Summary
Description
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosyn ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359213
  • ENSP00000352144
  • ENSG00000121578
  • ENST00000393765
  • ENSP00000377360
  • ENST00000483209
  • ENSP00000420161

Symbol
  • B4Gal-T4
  • beta4Gal-T4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.86
kinase perturbation
0.81
cell type or tissue
0.75
transcription factor binding site profile
0.63
cellular component
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
2
0
18.1
57.1
reticulocyte measurement
2
2
2
54.2
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
18.1
57.1
reticulocyte measurement
2
54.2
1
46.9
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 4
VGNC:8824
100608173
Macaque
beta-1,4-galactosyltransferase 4
711983
Mouse
MGI:1928387
56375
Rat
RGD:1307880
303923
Dog
beta-1,4-galactosyltransferase 4
VGNC:38352
608143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 4
Macaque
beta-1,4-galactosyltransferase 4
Mouse
Rat
Dog
beta-1,4-galactosyltransferase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60513-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Metabolism
Gene Ontology Terms (12)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (63)
1 – 10 of 63
CBWD3
Tdark
Novelty:  0.03639787
p_int:  0.999875024
p_ni:  0.000124938
p_wrong:  3.8e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
ITGA6
Tbio
Novelty:  0.00217985
p_int:  0.998447101
p_ni:  0.001552899
Score:  0.205
Data Source:  BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.993185255
p_ni:  0.006814722
p_wrong:  2.3e-8
Data Source:  BioPlex
NGLY1
Tbio
Family:  Enzyme
Novelty:  0.01017395
p_int:  0.988384015
p_ni:  0.011615985
Score:  0.532
Data Source:  BioPlex,STRINGDB
STRN3
Tbio
Novelty:  0.10331283
p_int:  0.827821523
p_ni:  0.172178477
Score:  0.169
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.824620295
p_ni:  0.175379705
Data Source:  BioPlex
SDF2L1
Tbio
Novelty:  0.12184663
p_int:  0.813722802
p_ni:  0.186277198
Score:  0.173
Data Source:  BioPlex,STRINGDB
CLDND1
Tbio
Novelty:  0.06681793
p_int:  0.769491351
p_ni:  0.23046246
p_wrong:  0.00004619
Score:  0.186
Data Source:  BioPlex,STRINGDB
B3GNT2
Tbio
Family:  Enzyme
Novelty:  0.02724566
Score:  0.962
Data Source:  STRINGDB
B3GNT5
Tbio
Family:  Enzyme
Novelty:  0.08038327
Score:  0.952
Data Source:  STRINGDB
Publication Statistics
PubMed Score  8.44

PubMed score by year
PubTator Score  4.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer