Tbio B4GALT4 Beta-1,4-galactosyltransferase 4

Protein Summary

Description

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60513
• Q68D68
• Q9BSW3
• Q9C078
• Beta-1,4-GalTase 4

Gene Name

• B4GALT4

Ensembl ID

• ENST00000359213
• ENSP00000352144
• ENSG00000121578
• ENST00000393765
• ENSP00000377360
• ENST00000483209
• ENSP00000420161

Symbol

• B4Gal-T4
• beta4Gal-T4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.86
kinase perturbation	0.81
cell type or tissue	0.75
transcription factor binding site profile	0.63
cellular component	0.6

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 4

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.01   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0