Tbio B4GALT4 Beta-1,4-galactosyltransferase 4

Protein Summary

Description

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60513
• Q68D68
• Q9BSW3
• Q9C078
• Beta-1,4-GalTase 4

Gene Name

• B4GALT4

Ensembl ID

• ENST00000359213
• ENSP00000352144
• ENSG00000121578
• ENST00000393765
• ENSP00000377360
• ENST00000483209
• ENSP00000420161

Symbol

• B4Gal-T4
• beta4Gal-T4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.86
kinase perturbation	0.81
cell type or tissue	0.75
transcription factor binding site profile	0.63
cellular component	0.6

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 4

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (63)

Explore Interacting Targets

1 – 10 of 63

• See Interactions on String-DB

CBWD3

Tdark

Novelty:  0.03639787

p_int:  0.999875024

p_ni:  0.000124938

p_wrong:  3.8e-8

Score:  0.179

Data Source:  BioPlex,STRINGDB

ITGA6

Tbio

Novelty:  0.00217985

p_int:  0.998447101

p_ni:  0.001552899

Score:  0.205

Data Source:  BioPlex,STRINGDB

HLA-DPA1

Tbio

Novelty:  0.01080446

p_int:  0.993185255

p_ni:  0.006814722

p_wrong:  2.3e-8

Data Source:  BioPlex

NGLY1

Tbio

Family:  Enzyme

Novelty:  0.01017395

p_int:  0.988384015

p_ni:  0.011615985

Score:  0.532

Data Source:  BioPlex,STRINGDB

STRN3

Tbio

Novelty:  0.10331283

p_int:  0.827821523

p_ni:  0.172178477

Score:  0.169

Data Source:  BioPlex,STRINGDB

HSPA5

Tchem

Novelty:  0.00043424

p_int:  0.824620295

p_ni:  0.175379705

Data Source:  BioPlex

SDF2L1

Tbio

Novelty:  0.12184663

p_int:  0.813722802

p_ni:  0.186277198

Score:  0.173

Data Source:  BioPlex,STRINGDB

CLDND1

Tbio

Novelty:  0.06681793

p_int:  0.769491351

p_ni:  0.23046246

p_wrong:  0.00004619

Score:  0.186

Data Source:  BioPlex,STRINGDB

B3GNT2

Tbio

Family:  Enzyme

Novelty:  0.02724566

Score:  0.962

Data Source:  STRINGDB

B3GNT5

Tbio

Family:  Enzyme

Novelty:  0.08038327

Score:  0.952

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (15)

Reactome (11)

KEGG (3)

UniProt (1)

Asparagine N-linked glycosylation (R-HSA-446203)

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1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	Glycosaminoglycan metabolism	122 targets	R-HSA-1630316
Reactome	Keratan sulfate biosynthesis	28 targets	R-HSA-2022854
Reactome	Keratan sulfate/keratin metabolism	33 targets	R-HSA-1638074
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Glycosaminoglycan metabolism	122 targets	R-HSA-1630316
Keratan sulfate biosynthesis	28 targets	R-HSA-2022854
Keratan sulfate/keratin metabolism	33 targets	R-HSA-1638074
Metabolism	2112 targets	R-HSA-1430728

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (12)

Functions (4)

Components (4)

Processes (4)

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1 – 4 of 4

GO Term	Evidence	Assigned by
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	Traceable Author Statement (TAS)	Reactome
galactosyltransferase activity	Traceable Author Statement (TAS)	ProtInc
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
N-acetyllactosamine synthase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations (null)

No disease associations found

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cortical surface area measurement	EFO_0010736	1	2	0	18.1	57.1
reticulocyte measurement	EFO_0010700	2	2	2		54.2
Hodgkins lymphoma	EFO_0000183	1	1	1		46.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cortical surface area measurement	EFO_0010736	0	18.1	57.1
reticulocyte measurement	EFO_0010700	2		54.2
Hodgkins lymphoma	EFO_0000183	1		46.9

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UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Membrane
Metal-binding
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
cortical surface area measurement
Hodgkins lymphoma
reticulocyte measurement

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	beta-1,4-galactosyltransferase 4	VGNC:8824	100608173
Macaque	beta-1,4-galactosyltransferase 4		711983
Mouse	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4	MGI:1928387	56375
Rat	beta-1,4-galactosyltransferase 4	RGD:1307880	303923
Dog	beta-1,4-galactosyltransferase 4	VGNC:38352	608143

Species	Name	OMA	EggNOG	Inparanoid
Chimp	beta-1,4-galactosyltransferase 4
Macaque	beta-1,4-galactosyltransferase 4
Mouse	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4
Rat	beta-1,4-galactosyltransferase 4
Dog	beta-1,4-galactosyltransferase 4

Publication Statistics

PubMed Score 8.44

PubMed score by year

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PubTator Score 4.81

PubTator score by year

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Related Publications

Text Mined References (11)

GeneRif Annotations (2)

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0 of 0

PMID	Year	Title