Tbio B4GALT4 Beta-1,4-galactosyltransferase 4

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 4

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Beta-1,4-galactosyltransferase 4

Protein Summary

Description

Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60513
• Q68D68
• Q9BSW3
• Q9C078
• Beta-1,4-GalTase 4

Gene Name

• B4GALT4

Ensembl ID

• ENST00000359213
• ENSP00000352144
• ENSG00000121578
• ENST00000393765
• ENSP00000377360
• ENST00000483209
• ENSP00000420161

Symbol

• B4Gal-T4
• beta4Gal-T4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.86
kinase perturbation	0.81
cell type or tissue	0.75
transcription factor binding site profile	0.63
cellular component	0.6

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 179   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.44   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cortical surface area measurement	EFO_0010736	1	2	0	18.1	57.1
reticulocyte measurement	EFO_0010700	2	2	2		54.2
Hodgkins lymphoma	EFO_0000183	1	1	1		46.9

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
cortical surface area measurement	EFO_0010736	0	18.1	57.1
reticulocyte measurement	EFO_0010700	2		54.2
Hodgkins lymphoma	EFO_0000183	1		46.9

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	beta-1,4-galactosyltransferase 4	VGNC:8824	100608173
Macaque	beta-1,4-galactosyltransferase 4		711983
Mouse	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4	MGI:1928387	56375
Rat	beta-1,4-galactosyltransferase 4	RGD:1307880	303923
Dog	beta-1,4-galactosyltransferase 4	VGNC:38352	608143

Species	Name	OMA	EggNOG	Inparanoid
Chimp	beta-1,4-galactosyltransferase 4
Macaque	beta-1,4-galactosyltransferase 4
Mouse	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4
Rat	beta-1,4-galactosyltransferase 4
Dog	beta-1,4-galactosyltransferase 4

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

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AF-O60513-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)

Reactome (11)

KEGG (3)

UniProt (1)

Asparagine N-linked glycosylation (R-HSA-446203)

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Find Similar Targets

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1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Reactome	Glycosaminoglycan metabolism	122 targets	R-HSA-1630316
Reactome	Keratan sulfate biosynthesis	28 targets	R-HSA-2022854
Reactome	Keratan sulfate/keratin metabolism	33 targets	R-HSA-1638074
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
Asparagine N-linked glycosylation	286 targets	R-HSA-446203
Glycosaminoglycan metabolism	122 targets	R-HSA-1630316
Keratan sulfate biosynthesis	28 targets	R-HSA-2022854
Keratan sulfate/keratin metabolism	33 targets	R-HSA-1638074
Metabolism	2112 targets	R-HSA-1430728

Gene Ontology Terms (12)

Functions (4)

Components (4)

Processes (4)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	Traceable Author Statement (TAS)	Reactome
galactosyltransferase activity	Traceable Author Statement (TAS)	ProtInc
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
N-acetyllactosamine synthase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Protein-Protein Interactions (63)

Explore Interacting Targets

1 – 10 of 63

• See Interactions on String-DB

CBWD3

Tdark

Novelty:  0.03639787

p_int:  0.999875024

p_ni:  0.000124938

p_wrong:  3.8e-8

Score:  0.179

Data Source:  BioPlex,STRINGDB

ITGA6

Tbio

Novelty:  0.00217985

p_int:  0.998447101

p_ni:  0.001552899

Score:  0.205

Data Source:  BioPlex,STRINGDB

HLA-DPA1

Tbio

Novelty:  0.01080446

p_int:  0.993185255

p_ni:  0.006814722

p_wrong:  2.3e-8

Data Source:  BioPlex

NGLY1

Tbio

Family:  Enzyme

Novelty:  0.01017395

p_int:  0.988384015

p_ni:  0.011615985

Score:  0.532

Data Source:  BioPlex,STRINGDB

STRN3

Tbio

Novelty:  0.10331283

p_int:  0.827821523

p_ni:  0.172178477

Score:  0.169

Data Source:  BioPlex,STRINGDB

HSPA5

Tchem

Novelty:  0.00043424

p_int:  0.824620295

p_ni:  0.175379705

Data Source:  BioPlex

SDF2L1

Tbio

Novelty:  0.12184663

p_int:  0.813722802

p_ni:  0.186277198

Score:  0.173

Data Source:  BioPlex,STRINGDB

CLDND1

Tbio

Novelty:  0.06681793

p_int:  0.769491351

p_ni:  0.23046246

p_wrong:  0.00004619

Score:  0.186

Data Source:  BioPlex,STRINGDB

B3GNT2

Tbio

Family:  Enzyme

Novelty:  0.02724566

Score:  0.962

Data Source:  STRINGDB

B3GNT5

Tbio

Family:  Enzyme

Novelty:  0.08038327

Score:  0.952

Data Source:  STRINGDB

Publication Statistics

PubMed Score  8.44

PubMed score by year

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PubTator Score  4.81

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

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Complete proteome
Disulfide bond
Glycoprotein
Glycosyltransferase
Golgi apparatus
Manganese
Membrane
Metal-binding
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
cortical surface area measurement
Hodgkins lymphoma
reticulocyte measurement