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Tbio
B4GALT3
Beta-1,4-galactosyltransferase 3

Protein Summary
Description
Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the fi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319769
  • ENSP00000320965
  • ENSG00000158850
  • ENST00000367998
  • ENSP00000356977
  • ENST00000622395
  • ENSP00000480428

Symbol
  • beta4Gal-T3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
virus perturbation
0.85
disease perturbation
0.83
kinase perturbation
0.81
transcription factor binding site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.69   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
UBE4A
Tbio
Novelty:  0.02576018
p_int:  0.994966428
p_ni:  0.005033521
p_wrong:  5.1e-8
Score:  0.158
Data Source:  BioPlex,STRINGDB
ATP5MC1
Tbio
Family:  Enzyme
Novelty:  0.03538978
p_int:  0.99292798
p_ni:  0.007072019
p_wrong:  2e-9
Score:  0.656
Data Source:  BioPlex,STRINGDB
TMEM120A
Tdark
Novelty:  0.21664358
p_int:  0.990365941
p_ni:  0.009541968
p_wrong:  0.000092091
Score:  0.719
Data Source:  BioPlex,STRINGDB
GALNT6
Tbio
Family:  Enzyme
Novelty:  0.04627605
p_int:  0.962281292
p_ni:  0.037718708
Score:  0.213
Data Source:  BioPlex,STRINGDB
XYLT2
Tbio
Family:  Enzyme
Novelty:  0.00273033
p_int:  0.952482097
p_ni:  0.047517903
Score:  0.617
Data Source:  BioPlex,STRINGDB
SLC19A2
Tbio
Family:  Transporter
Novelty:  0.00761796
p_int:  0.950847182
p_ni:  0.049041654
p_wrong:  0.000111164
Score:  0.546
Data Source:  BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.940001382
p_ni:  0.059998618
Data Source:  BioPlex
ASPHD2
Tdark
Family:  Enzyme
Novelty:  1.24088719
p_int:  0.934206594
p_ni:  0.065657602
p_wrong:  0.000135804
Score:  0.158
Data Source:  BioPlex,STRINGDB
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.921738689
p_ni:  0.078256982
p_wrong:  0.00000433
Data Source:  BioPlex
CRP
Tbio
Novelty:  0.00001517
p_int:  0.907126161
p_ni:  0.092873839
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
2
2
92.2
high density lipoprotein cholesterol measurement
32
3
32
92
4
2
0
1.1
90
asthma
6
2
1
1
84.5
mean platelet volume
3
2
4
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
92.2
high density lipoprotein cholesterol measurement
32
92
0
1.1
90
asthma
1
1
84.5
mean platelet volume
4
84.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 3
VGNC:8910
457451
Macaque
beta-1,4-galactosyltransferase 3
719920
Mouse
MGI:1928767
57370
Rat
RGD:1359221
494342
Dog
beta-1,4-galactosyltransferase 3
VGNC:38351
488650
Species
Name
OMA
EggNOG
Inparanoid
Chimp
beta-1,4-galactosyltransferase 3
Macaque
beta-1,4-galactosyltransferase 3
Mouse
Rat
Dog
beta-1,4-galactosyltransferase 3
Publication Statistics
PubMed Score 24.69
PubMed score by year
PubTator Score 8.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title