CDC40
Pre-mRNA-processing factor 17
Protein Summary
Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing. Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]
- ENST00000307731
- ENSP00000304370
- ENSG00000168438
- ENST00000368932
- ENSP00000357928
- EHB3
- PRP17
- PRPF17
- EHB3
- PRP17
- PRPF17
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.74 | ||
histone modification site profile | 0.74 | ||
virus perturbation | 0.72 | ||
kinase perturbation | 0.6 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.11 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 123 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.11 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 123 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0