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Tbio
CDC40
Pre-mRNA-processing factor 17

Protein Summary
Description
Associates with the spliceosome late in the splicing pathway and may function in the second step of pre-mRNA splicing. Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307731
  • ENSP00000304370
  • ENSG00000168438
  • ENST00000368932
  • ENSP00000357928

Symbol
  • EHB3
  • PRP17
  • PRPF17
  • EHB3
  • PRP17
  • PRPF17
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
histone modification site profile
0.74
virus perturbation
0.72
kinase perturbation
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.61   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.61   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (324)
1 – 10 of 324
NKAPD1
Tdark
Novelty: 1.56979675
p_int: 0.999953418
p_ni: 0.000046581
Data Source: BioPlex
SYF2
Tbio
Novelty: 0.06114903
p_int: 0.999908178
p_ni: 0.000091821
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.02033423
p_int: 0.999902433
p_ni: 0.000097567
Score: 0.997
Data Source: BioPlex,STRINGDB
USB1
Tbio
Family: Enzyme
Novelty: 0.01677996
p_int: 0.999874087
p_ni: 0.000125908
p_wrong: 4e-9
Score: 0.377
Data Source: BioPlex,STRINGDB
BCAS2
Tbio
Novelty: 0.05425016
p_int: 0.999872115
p_ni: 0.000127884
Score: 0.999
Data Source: BioPlex,STRINGDB
ELAVL2
Tbio
Novelty: 0.00370708
p_int: 0.999822828
p_ni: 0.000177171
p_wrong: 2e-9
Score: 0.909
Data Source: BioPlex,STRINGDB
PRPF19
Tbio
Novelty: 0.01616737
p_int: 0.999627447
p_ni: 0.000372549
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SNRPA1
Tbio
Novelty: 0.01232044
p_int: 0.999624882
p_ni: 0.000375118
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
TSSC4
Tdark
Novelty: 0.17064786
p_int: 0.999468335
p_ni: 0.00053166
p_wrong: 4e-9
Score: 0.395
Data Source: BioPlex,STRINGDB
SNRPF
Tdark
Novelty: 0.17624854
p_int: 0.999225881
p_ni: 0.000774119
Score: 0.997
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  32.61

PubMed score by year
PubTator Score  5.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer