You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TPST1
Protein-tyrosine sulfotransferase 1

Protein Classes
Protein Summary
Description
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304842
  • ENSP00000302413
  • ENSG00000169902
  • ENST00000649664
  • ENSP00000497281

Symbol
  • TANGO13A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
disease perturbation
0.79
kinase perturbation
0.66
tissue sample
0.66
transcription factor binding site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.91   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.91   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
1
1
40.7
myeloid white cell count
1
1
1
21.4
leukocyte count
1
1
1
12
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
1
40.7
myeloid white cell count
1
21.4
leukocyte count
1
12
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tyrosylprotein sulfotransferase 1
VGNC:4549
472398
Macaque
tyrosylprotein sulfotransferase 1
696626
Mouse
MGI:1298231
22021
Rat
RGD:1308473
288617
Dog
tyrosylprotein sulfotransferase 1
VGNC:47755
489788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tyrosylprotein sulfotransferase 1
Macaque
tyrosylprotein sulfotransferase 1
Mouse
Rat
Dog
tyrosylprotein sulfotransferase 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60507-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (5)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (37)
1 – 10 of 37
TPST2
Tbio
Family:  Enzyme
Novelty:  0.02551048
p_int:  0.99999988
p_ni:  7.1e-8
p_wrong:  4.9e-8
Data Source:  BioPlex
ADGRE5
Tbio
Family:  GPCR
Novelty:  0.01137558
p_int:  0.999996291
p_ni:  0.000003363
p_wrong:  3.46e-7
Data Source:  BioPlex
SCGB2A2
Tbio
Novelty:  0.01594053
p_int:  0.999904248
p_ni:  0.000054208
p_wrong:  0.000041544
Data Source:  BioPlex
B2M
Tbio
Novelty:  0.00011248
p_int:  0.999839163
p_ni:  0.000122084
p_wrong:  0.000038753
Score:  0.19
Data Source:  BioPlex,STRINGDB
ACTB
Tbio
Novelty:  0.00006048
p_int:  0.812561996
p_ni:  0.187438004
Score:  0.246
Data Source:  BioPlex,STRINGDB
GINM1
Tdark
Novelty:  1.0701107
p_int:  0.801926825
p_ni:  0.000038942
p_wrong:  0.198034233
Score:  0.159
Data Source:  BioPlex,STRINGDB
PODXL2
Tbio
Novelty:  0.09100487
Score:  0.904
Data Source:  Reactome,STRINGDB
SBDS
Tbio
Novelty:  0.00818779
Score:  0.743
Data Source:  STRINGDB
WDR33
Tbio
Novelty:  0.09221439
Score:  0.719
Data Source:  STRINGDB
SLC35B3
Tdark
Family:  Transporter
Novelty:  0.10252233
Score:  0.685
Data Source:  STRINGDB
Publication Statistics
PubMed Score  30.91

PubMed score by year
PubTator Score  12.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: