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Tbio
TPST1
Protein-tyrosine sulfotransferase 1

Protein Classes
Protein Summary
Description
Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304842
  • ENSP00000302413
  • ENSG00000169902
  • ENST00000649664
  • ENSP00000497281

Symbol
  • TANGO13A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
disease perturbation
0.79
kinase perturbation
0.66
tissue sample
0.66
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.49   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.49   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (37)
1 – 10 of 37
TPST2
Tbio
Family: Enzyme
Novelty: 0.02551048
p_int: 0.99999988
p_ni: 7.1e-8
p_wrong: 4.9e-8
Data Source: BioPlex
ADGRE5
Tbio
Family: GPCR
Novelty: 0.01137558
p_int: 0.999996291
p_ni: 0.000003363
p_wrong: 3.46e-7
Data Source: BioPlex
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.999904248
p_ni: 0.000054208
p_wrong: 0.000041544
Data Source: BioPlex
B2M
Tbio
Novelty: 0.00011248
p_int: 0.999839163
p_ni: 0.000122084
p_wrong: 0.000038753
Score: 0.19
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.812561996
p_ni: 0.187438004
Score: 0.246
Data Source: BioPlex,STRINGDB
GINM1
Tdark
Novelty: 1.0701107
p_int: 0.801926825
p_ni: 0.000038942
p_wrong: 0.198034233
Score: 0.159
Data Source: BioPlex,STRINGDB
PODXL2
Tbio
Novelty: 0.09100487
Score: 0.904
Data Source: Reactome,STRINGDB
SBDS
Tbio
Novelty: 0.00818779
Score: 0.743
Data Source: STRINGDB
WDR33
Tbio
Novelty: 0.09221439
Score: 0.719
Data Source: STRINGDB
SLC35B3
Tdark
Family: Transporter
Novelty: 0.10252233
Score: 0.685
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.49

PubMed score by year
PubTator Score  12.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer