Tchem OGA Protein O-GlcNAcase

Protein Summary

Description

Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O60502
• B7WPB9
• D3DR79
• E9PGF9
• O75166
• Q86WV0
• Q8IV98
• Q9BVA5
• Q9HAR0
• OGA

Gene Name

• OGA

Ensembl ID

• ENST00000357797
• ENSP00000350445
• ENSG00000198408
• ENST00000361464
• ENSP00000354850
• ENST00000370094
• ENSP00000359112
• ENST00000439817
• ENSP00000409973

Symbol

• HEXC
• KIAA0679
• MEA5
• MGEA5
• MEA5
• MGEA5
• NCOAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
transcription factor perturbation	0.94
transcription factor binding site profile	0.89
kinase perturbation	0.84
disease perturbation	0.83

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2724.97   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2724.97   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 192

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0