Tchem OGA Protein O-GlcNAcase

Protein Summary

Description

Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• O60502
• B7WPB9
• D3DR79
• E9PGF9
• O75166
• Q86WV0
• Q8IV98
• Q9BVA5
• Q9HAR0
• OGA

Gene Name

• OGA

Ensembl ID

• ENST00000357797
• ENSP00000350445
• ENSG00000198408
• ENST00000361464
• ENSP00000354850
• ENST00000370094
• ENSP00000359112
• ENST00000439817
• ENSP00000409973

Symbol

• HEXC
• KIAA0679
• MEA5
• MGEA5
• MEA5
• MGEA5
• NCOAT

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
transcription factor perturbation	0.94
transcription factor binding site profile	0.89
kinase perturbation	0.84
disease perturbation	0.83

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2564.3   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2564.3   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 158

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (158)

Explore Active Ligands

1 – 10 of 158

CHEMBL257158

OGATchem Enzyme

Ki : 6.75

US9243020, 17

OGATchem Enzyme

Ki : 9.26

NAG-thiazoline

OGATchem Enzyme

Ki : 7.16

US8901087, 2

OGATchem Enzyme

Ki : 10.3

US8901087, 27

OGATchem Enzyme

Ki : 9.92

US9120781, 18

OGATchem Enzyme

Ki : 9.89

US8901087, 191

OGATchem Enzyme

Ki : 9.85

US9126957, 10

OGATchem Enzyme

Ki : 9.85

US8901087, 95

OGATchem Enzyme

Ki : 9.8

US8901087, 1

OGATchem Enzyme

Ki : 9.77

GWAS Traits (8)

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5

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intelligence	EFO_0004337	3	5	3	7.2	86.9
self reported educational attainment	EFO_0004784	3	4	4		84.6
mathematical ability	EFO_0004875	4	2	4		80.4
household income	EFO_0009695	1	3	3		73.8
cognitive function measurement	EFO_0008354	2	1	2		68.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
intelligence	EFO_0004337	3	7.2	86.9
self reported educational attainment	EFO_0004784	4		84.6
mathematical ability	EFO_0004875	4		80.4
household income	EFO_0009695	3		73.8
cognitive function measurement	EFO_0008354	2		68.8

Reset Zoom  Beta Count   Odds Ratio

Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	meningioma expressed antigen 5 (hyaluronidase)		450691
Macaque	meningioma expressed antigen 5 (hyaluronidase)		712370
Mouse	meningioma expressed antigen 5 (hyaluronidase)	MGI:1932139	76055
Rat	O-GlcNAcase	RGD:621077	154968
Dog	O-GlcNAcase	VGNC:54337	477802

Species	Name	OMA	EggNOG	Inparanoid
Chimp	meningioma expressed antigen 5 (hyaluronidase)
Macaque	meningioma expressed antigen 5 (hyaluronidase)
Mouse	meningioma expressed antigen 5 (hyaluronidase)
Rat	O-GlcNAcase
Dog	O-GlcNAcase

Protein Structure (17 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

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More information can be found at RCSB PDB

AF-O60502-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (1)

KEGG (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Insulin resistance	108 targets	path:hsa04931

Name	Explore in Pharos	Explore in Source
Insulin resistance	108 targets	path:hsa04931

Gene Ontology Terms (14)

Functions (5)

Components (3)

Processes (6)

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GO Term	Evidence	Assigned by
beta-N-acetylglucosaminidase activity	Inferred from Direct Assay (IDA)	UniProtKB
hyalurononglucosaminidase activity	Traceable Author Statement (TAS)	ProtInc
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC
[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Protein-Protein Interactions (133)

Explore Interacting Targets

1 – 10 of 133

• See Interactions on String-DB

HINT1

Tchem

Novelty:  0.00815168

p_int:  0.99967853

p_ni:  0.00032147

Data Source:  BioPlex

ACYP2

Tbio

Family:  Enzyme

Novelty:  0.03063981

p_int:  0.992156295

p_ni:  0.007843704

Data Source:  BioPlex

BMT2

Tbio

Family:  Enzyme

Novelty:  0.05916379

p_int:  0.989560445

p_ni:  0.010439555

Score:  0.175

Data Source:  BioPlex,STRINGDB

LACTB2

Tbio

Family:  Enzyme

Novelty:  0.1868172

p_int:  0.989322558

p_ni:  0.010677442

Score:  0.54

Data Source:  BioPlex,STRINGDB

EMC9

Tdark

Novelty:  0.52441743

p_int:  0.977776227

p_ni:  0.022223773

Score:  0.188

Data Source:  BioPlex,STRINGDB

RIDA

Tbio

Family:  Enzyme

Novelty:  0.01795892

p_int:  0.972138262

p_ni:  0.027861738

Score:  0.19

Data Source:  BioPlex,STRINGDB

C10orf91

Tdark

p_int:  0.967396256

p_ni:  0.03260374

p_wrong:  5e-9

Data Source:  BioPlex

STN1

Tbio

Novelty:  0.01309587

p_int:  0.951772269

p_ni:  0.048227731

Data Source:  BioPlex

PPP1R18

Tbio

Novelty:  0.18837599

p_int:  0.892540293

p_ni:  0.107459705

p_wrong:  1e-9

Score:  0.243

Data Source:  BioPlex,STRINGDB

FMO5

Tbio

Family:  Enzyme

Novelty:  0.05610368

p_int:  0.859167292

p_ni:  0.140832708

Score:  0.219

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  2564.30

PubMed score by year

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PubTator Score  2103.57

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
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Cytoplasm
Glycosidase
Host-virus interaction
Hydrolase
Nucleus
Phosphoprotein
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GWAS Trait Find Similar Targets

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atrial fibrillation
cognitive function measurement
heel bone mineral density
household income
intelligence
mathematical ability
self reported educational attainment
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

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cellular phenotype
growth/size/body region phenotype
mortality/aging
respiratory system phenotype