Protein Summary
Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
- ENST00000357797
- ENSP00000350445
- ENSG00000198408
- ENST00000361464
- ENSP00000354850
- ENST00000370094
- ENSP00000359112
- ENST00000439817
- ENSP00000409973
- HEXC
- KIAA0679
- MEA5
- MGEA5
- MEA5
- MGEA5
- NCOAT
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological process | 0.99 | ||
transcription factor perturbation | 0.94 | ||
transcription factor binding site profile | 0.89 | ||
kinase perturbation | 0.84 | ||
disease perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2564.3 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 159 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2564.3 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 159 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 158
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (158)
Protein-Protein Interactions (133)
ACYP2
Family: Enzyme
Novelty: 0.03063981
p_int: 0.992156295
p_ni: 0.007843704
Data Source: BioPlex
BMT2
Family: Enzyme
Novelty: 0.05916379
p_int: 0.989560445
p_ni: 0.010439555
Score: 0.175
Data Source: BioPlex,STRINGDB
LACTB2
Family: Enzyme
Novelty: 0.1868172
p_int: 0.989322558
p_ni: 0.010677442
Score: 0.54
Data Source: BioPlex,STRINGDB
EMC9
Novelty: 0.52441743
p_int: 0.977776227
p_ni: 0.022223773
Score: 0.188
Data Source: BioPlex,STRINGDB
RIDA
Family: Enzyme
Novelty: 0.01795892
p_int: 0.972138262
p_ni: 0.027861738
Score: 0.19
Data Source: BioPlex,STRINGDB
PPP1R18
Novelty: 0.18837599
p_int: 0.892540293
p_ni: 0.107459705
p_wrong: 1e-9
Score: 0.243
Data Source: BioPlex,STRINGDB
FMO5
Family: Enzyme
Novelty: 0.05610368
p_int: 0.859167292
p_ni: 0.140832708
Score: 0.219
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
KEGG | Insulin resistance | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Insulin resistance | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (5)
Components (3)
Processes (6)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
intelligence | 3 | 5 | 3 | 7.2 | 86.9 | ||||
self reported educational attainment | 3 | 4 | 4 | 84.6 | |||||
mathematical ability | 4 | 2 | 4 | 80.4 | |||||
household income | 1 | 3 | 3 | 73.8 | |||||
cognitive function measurement | 2 | 1 | 2 | 68.8 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
intelligence | 3 | 7.2 | 86.9 | ||||
self reported educational attainment | 4 | 84.6 | |||||
mathematical ability | 4 | 80.4 | |||||
household income | 3 | 73.8 | |||||
cognitive function measurement | 2 | 68.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (16)
1 – 5 of 16
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | meningioma expressed antigen 5 (hyaluronidase) | 450691 | ||||||
Macaque | meningioma expressed antigen 5 (hyaluronidase) | 712370 | ||||||
Mouse | MGI:1932139 | 76055 | ||||||
Rat | RGD:621077 | 154968 | ||||||
Dog | O-GlcNAcase | VGNC:54337 | 477802 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | meningioma expressed antigen 5 (hyaluronidase) | |||||
Macaque | meningioma expressed antigen 5 (hyaluronidase) | |||||
Mouse | ||||||
Rat | ||||||
Dog | O-GlcNAcase | |||||
Publication Statistics
PubMed Score 2564.30
PubMed score by year
PubTator Score 2103.57
PubTator score by year
Related Publications
Text Mined References (48)
GeneRif Annotations (31)
Items per page:
0 of 0
PMID | Year | Title |
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