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Tchem
OGA
Protein O-GlcNAcase

Protein Summary
Description
Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:11148210). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (PubMed:24088714). Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357797
  • ENSP00000350445
  • ENSG00000198408
  • ENST00000361464
  • ENSP00000354850
  • ENST00000370094
  • ENSP00000359112
  • ENST00000439817
  • ENSP00000409973

Symbol
  • HEXC
  • KIAA0679
  • MEA5
  • MGEA5
  • MEA5
  • MGEA5
  • NCOAT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
transcription factor perturbation
0.94
transcription factor binding site profile
0.89
kinase perturbation
0.84
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2564.3   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2564.3   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 158
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
5
3
7.2
86.9
self reported educational attainment
3
4
4
84.6
mathematical ability
4
2
4
80.4
household income
1
3
3
73.8
cognitive function measurement
2
1
2
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
7.2
86.9
self reported educational attainment
4
84.6
mathematical ability
4
80.4
household income
3
73.8
cognitive function measurement
2
68.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
meningioma expressed antigen 5 (hyaluronidase)
450691
Macaque
meningioma expressed antigen 5 (hyaluronidase)
712370
Mouse
MGI:1932139
76055
Rat
RGD:621077
154968
Dog
O-GlcNAcase
VGNC:54337
477802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
meningioma expressed antigen 5 (hyaluronidase)
Macaque
meningioma expressed antigen 5 (hyaluronidase)
Mouse
Rat
Dog
O-GlcNAcase
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O60502-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (133)
1 – 10 of 133
HINT1
Tchem
Novelty:  0.00815168
p_int:  0.99967853
p_ni:  0.00032147
Data Source:  BioPlex
ACYP2
Tbio
Family:  Enzyme
Novelty:  0.03063981
p_int:  0.992156295
p_ni:  0.007843704
Data Source:  BioPlex
BMT2
Tbio
Family:  Enzyme
Novelty:  0.05916379
p_int:  0.989560445
p_ni:  0.010439555
Score:  0.175
Data Source:  BioPlex,STRINGDB
LACTB2
Tbio
Family:  Enzyme
Novelty:  0.1868172
p_int:  0.989322558
p_ni:  0.010677442
Score:  0.54
Data Source:  BioPlex,STRINGDB
EMC9
Tdark
Novelty:  0.52441743
p_int:  0.977776227
p_ni:  0.022223773
Score:  0.188
Data Source:  BioPlex,STRINGDB
RIDA
Tbio
Family:  Enzyme
Novelty:  0.01795892
p_int:  0.972138262
p_ni:  0.027861738
Score:  0.19
Data Source:  BioPlex,STRINGDB
C10orf91
Tdark
p_int:  0.967396256
p_ni:  0.03260374
p_wrong:  5e-9
Data Source:  BioPlex
STN1
Tbio
Novelty:  0.01309587
p_int:  0.951772269
p_ni:  0.048227731
Data Source:  BioPlex
PPP1R18
Tbio
Novelty:  0.18837599
p_int:  0.892540293
p_ni:  0.107459705
p_wrong:  1e-9
Score:  0.243
Data Source:  BioPlex,STRINGDB
FMO5
Tbio
Family:  Enzyme
Novelty:  0.05610368
p_int:  0.859167292
p_ni:  0.140832708
Score:  0.219
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2564.30

PubMed score by year
PubTator Score  2103.57

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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