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Tbio
DOK2
Docking protein 2

Protein Summary
Description
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276420
  • ENSP00000276420
  • ENSG00000147443

Symbol
  • p56DOK
  • p56dok-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.69
cell type or tissue
0.62
transcription factor binding site profile
0.62
biological term
0.6
hub protein
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.12   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 626   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.12   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 626   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
1
2
81.7
lymphocyte count
2
1
2
70.5
body height
1
1
1
58.5
1
1
0
1.9
53.2
neutrophil count
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
81.7
lymphocyte count
2
70.5
body height
1
58.5
0
1.9
53.2
neutrophil count
1
43.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
docking protein 2
VGNC:2457
464036
Macaque
docking protein 2
706317
Mouse
MGI:1332623
13449
Rat
RGD:1310966
290361
Dog
docking protein 2
VGNC:40056
486133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
docking protein 2
Macaque
docking protein 2
Mouse
Rat
Dog
docking protein 2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (18)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cell surface interactions at the vascular wall
Reactome
Developmental Biology
Reactome
Hemostasis
Reactome
RET signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Cell surface interactions at the vascular wall
Developmental Biology
Hemostasis
RET signaling
Protein-Protein Interactions (104)
1 – 10 of 104
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
p_int: 0.999916588
p_ni: 0.000083412
Score: 0.35
Data Source: BioPlex,STRINGDB
LANCL2
Tchem
Novelty: 0.06086418
p_int: 0.995901872
p_ni: 0.004098126
p_wrong: 1e-9
Score: 0.787
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02220251
p_int: 0.994969789
p_ni: 0.005030211
Score: 0.77
Data Source: BioPlex,STRINGDB
FAM120B
Tbio
Novelty: 0.07982799
p_int: 0.992734616
p_ni: 0.007262228
p_wrong: 0.000003156
Score: 0.187
Data Source: BioPlex,STRINGDB
MINDY3
Tbio
Novelty: 0.02865765
p_int: 0.968557897
p_ni: 0.031442103
Score: 0.309
Data Source: BioPlex,STRINGDB
CENPM
Tbio
Novelty: 0.0671332
p_int: 0.967830553
p_ni: 0.026011133
p_wrong: 0.006158314
Score: 0.519
Data Source: BioPlex,STRINGDB
HVCN1
Tchem
Family: IC
Novelty: 0.00195009
p_int: 0.967830553
p_ni: 0.026011133
p_wrong: 0.006158314
Score: 0.3
Data Source: BioPlex,STRINGDB
TMEM38A
Tbio
Family: IC
Novelty: 0.10891929
p_int: 0.967830553
p_ni: 0.026011133
p_wrong: 0.006158314
Score: 0.295
Data Source: BioPlex,STRINGDB
COQ8A
Tbio
Family: Kinase
Novelty: 0.01672738
p_int: 0.959037018
p_ni: 0.040962982
Score: 0.297
Data Source: BioPlex,STRINGDB
EVI2A
Tbio
Novelty: 0.02320553
p_int: 0.864279256
p_ni: 0.135720744
Score: 0.324
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  40.12

PubMed score by year
PubTator Score  25.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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