Protein Summary
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of ...more
- ENST00000377833
- ENSP00000367064
- ENSG00000107611
- IFCR
- IFCR
- MGA1
- gp280
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
protein domain | 0.99 | ||
gene perturbation | 0.93 | ||
disease | 0.77 | ||
cellular component | 0.74 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 222.14 (req: < 5)
Gene RIFs: 44 (req: <= 3)
Antibodies: 139 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 222.14 (req: >= 5)
Gene RIFs: 44 (req: > 3)
Antibodies: 139 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
albuminuria | 3 | 5 | 8 | 99.6 | |||||
urinary albumin to creatinine ratio | 7 | 8 | 14 | 99.5 | |||||
Moderate albuminuria | 2 | 2 | 1 | 1.8 | 91.6 | ||||
1 | 1 | 1 | 79.7 | ||||||
Proteinuria | 2 | 1 | 0 | 1.1 | 72.2 | ||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
albuminuria | 8 | 99.6 | |||||
urinary albumin to creatinine ratio | 14 | 99.5 | |||||
Moderate albuminuria | 1 | 1.8 | 91.6 | ||||
1 | 79.7 | ||||||
Proteinuria | 0 | 1.1 | 72.2 | ||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cubilin | VGNC:5385 | 450327 | |||||
Macaque | cubilin [Source:HGNC Symbol;Acc:HGNC:2548] | |||||||
Mouse | MGI:1931256 | 65969 | ||||||
Rat | RGD:68355 | 80848 | ||||||
Dog | cubilin | VGNC:39725 | 403767 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cubilin | |||||
Macaque | cubilin [Source:HGNC Symbol;Acc:HGNC:2548] | |||||
Mouse | ||||||
Rat | ||||||
Dog | cubilin | |||||
Protein Structure (1 Structure, 13 AlphaFold Models)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (20)
Reactome (17)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 17
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defective AMN causes hereditary megaloblastic anemia 1 | ||||
Reactome | Defective CUBN causes hereditary megaloblastic anemia 1 | ||||
Reactome | Defects in cobalamin (B12) metabolism | ||||
Reactome | Defects in vitamin and cofactor metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defective AMN causes hereditary megaloblastic anemia 1 | ||||
Defective CUBN causes hereditary megaloblastic anemia 1 | ||||
Defects in cobalamin (B12) metabolism | ||||
Defects in vitamin and cofactor metabolism | ||||
Gene Ontology Terms (49)
Functions (9)
Components (20)
Processes (20)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (62)
1 – 10 of 62
LRP2
Novelty: 0.00143258
Score: 0.997
Data Source: STRINGDB
GIF
Novelty: 0.00508343
Score: 0.997
Data Source: Reactome,STRINGDB
AMN
Novelty: 0.030358
Score: 0.993
Data Source: Reactome,STRINGDB
GC
Novelty: 0.00065382
Score: 0.978
Data Source: Reactome,STRINGDB
APOA1
Novelty: 0.0001216
Score: 0.943
Data Source: Reactome,STRINGDB
LGMN
Family: Enzyme
Novelty: 0.00296582
Score: 0.914
Data Source: STRINGDB
ALB
Novelty: 0.00000616
Score: 0.771
Data Source: STRINGDB
CLCN5
Family: IC
Novelty: 0.00419772
Score: 0.684
Data Source: STRINGDB
TCN1
Novelty: 0.00305315
Score: 0.677
Data Source: STRINGDB
TCN2
Novelty: 0.00213334
Score: 0.671
Data Source: STRINGDB
Publication Statistics
PubMed Score 222.14
PubMed score by year
PubTator Score 109.67
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
GWAS Trait