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Tbio
CUBN
Cubilin

Protein Summary
Description
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377833
  • ENSP00000367064
  • ENSG00000107611

Symbol
  • IFCR
  • IFCR
  • MGA1
  • gp280
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
protein domain
0.99
gene perturbation
0.93
disease
0.77
cellular component
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.14   (req: < 5)
Gene RIFs: 44   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 222.14   (req: >= 5)
Gene RIFs: 44   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albuminuria
3
5
8
99.6
urinary albumin to creatinine ratio
7
8
14
99.5
Moderate albuminuria
2
2
1
1.8
91.6
1
1
1
79.7
Proteinuria
2
1
0
1.1
72.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albuminuria
8
99.6
urinary albumin to creatinine ratio
14
99.5
Moderate albuminuria
1
1.8
91.6
1
79.7
Proteinuria
0
1.1
72.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cubilin
VGNC:5385
450327
Macaque
cubilin [Source:HGNC Symbol;Acc:HGNC:2548]
Mouse
MGI:1931256
65969
Rat
RGD:68355
80848
Dog
cubilin
VGNC:39725
403767
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cubilin
Macaque
cubilin [Source:HGNC Symbol;Acc:HGNC:2548]
Mouse
Rat
Dog
cubilin
Protein Structure (1 Structure, 13 AlphaFold Models)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cobalamin (Cbl, vitamin B12) transport and metabolism
Reactome
Defective AMN causes hereditary megaloblastic anemia 1
Reactome
Defective CUBN causes hereditary megaloblastic anemia 1
Reactome
Defects in cobalamin (B12) metabolism
Reactome
Defects in vitamin and cofactor metabolism
Name
Explore in Pharos
Explore in Source
Cobalamin (Cbl, vitamin B12) transport and metabolism
Defective AMN causes hereditary megaloblastic anemia 1
Defective CUBN causes hereditary megaloblastic anemia 1
Defects in cobalamin (B12) metabolism
Defects in vitamin and cofactor metabolism
Gene Ontology Terms (49)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (62)
1 – 10 of 62
LRP2
Tbio
Novelty: 0.00143258
Score: 0.997
Data Source: STRINGDB
GIF
Tbio
Novelty: 0.00508343
Score: 0.997
Data Source: Reactome,STRINGDB
AMN
Tbio
Novelty: 0.030358
Score: 0.993
Data Source: Reactome,STRINGDB
GC
Tchem
Novelty: 0.00065382
Score: 0.978
Data Source: Reactome,STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.943
Data Source: Reactome,STRINGDB
LGMN
Tchem
Family: Enzyme
Novelty: 0.00296582
Score: 0.914
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.771
Data Source: STRINGDB
CLCN5
Tbio
Family: IC
Novelty: 0.00419772
Score: 0.684
Data Source: STRINGDB
TCN1
Tbio
Novelty: 0.00305315
Score: 0.677
Data Source: STRINGDB
TCN2
Tbio
Novelty: 0.00213334
Score: 0.671
Data Source: STRINGDB
Publication Statistics
PubMed Score  222.14

PubMed score by year
PubTator Score  109.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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