Protein Summary
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of ...more
- ENST00000377833
- ENSP00000367064
- ENSG00000107611
- IFCR
- IFCR
- MGA1
- gp280
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 1 | ||
protein domain | 0.99 | ||
gene perturbation | 0.93 | ||
disease | 0.77 | ||
cellular component | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.67 (req: < 5)
Gene RIFs: 44 (req: <= 3)
Antibodies: 139 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 227.67 (req: >= 5)
Gene RIFs: 44 (req: > 3)
Antibodies: 139 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 29
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (62)
Nearest Tclin Targets
Pathways (20)
Reactome (17)
KEGG (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Reactome | Defective AMN causes hereditary megaloblastic anemia 1 | ||||
Reactome | Defective CUBN causes hereditary megaloblastic anemia 1 | ||||
Reactome | Defects in cobalamin (B12) metabolism | ||||
Reactome | Defects in vitamin and cofactor metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cobalamin (Cbl, vitamin B12) transport and metabolism | ||||
Defective AMN causes hereditary megaloblastic anemia 1 | ||||
Defective CUBN causes hereditary megaloblastic anemia 1 | ||||
Defects in cobalamin (B12) metabolism | ||||
Defects in vitamin and cofactor metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (49)
Functions (9)
Components (20)
Processes (20)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
urinary albumin to creatinine ratio | 7 | 9 | 15 | 99.4 | |||||
albuminuria | 3 | 5 | 8 | 98.8 | |||||
Moderate albuminuria | 2 | 2 | 1 | 1.8 | 94.7 | ||||
urinary microalbumin measurement | 1 | 4 | 4 | 93.1 | |||||
total cholesterol measurement | 3 | 2 | 3 | 78.7 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
urinary albumin to creatinine ratio | 15 | 99.4 | |||||
albuminuria | 8 | 98.8 | |||||
Moderate albuminuria | 1 | 1.8 | 94.7 | ||||
urinary microalbumin measurement | 4 | 93.1 | |||||
total cholesterol measurement | 3 | 78.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cubilin | VGNC:5385 | 450327 | |||||
Macaque | cubilin [Source:HGNC Symbol;Acc:HGNC:2548] | |||||||
Mouse | MGI:1931256 | 65969 | ||||||
Rat | RGD:68355 | 80848 | ||||||
Dog | cubilin | VGNC:39725 | 403767 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cubilin | |||||
Macaque | cubilin [Source:HGNC Symbol;Acc:HGNC:2548] | |||||
Mouse | ||||||
Rat | ||||||
Dog | cubilin | |||||
Publication Statistics
PubMed Score 227.67
PubMed score by year
PubTator Score 109.67
PubTator score by year
Related Publications
Text Mined References (82)
GeneRif Annotations (44)
Items per page:
0 of 0
PMID | Year | Title |
|---|