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Tbio
ACSL4
Long-chain-fatty-acid--CoA ligase 4

Protein Classes
Protein Summary
Description
Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340800
  • ENSP00000339787
  • ENSG00000068366
  • ENST00000348502
  • ENSP00000262835
  • ENST00000469796
  • ENSP00000419171

Symbol
  • ACS4
  • FACL4
  • LACS4
  • ACS4
  • FACL4
  • LACS4
  • MRX63
  • MRX68
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
molecular function
0.91
microRNA
0.83
cellular component
0.78
histone modification site profile
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.47   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 316   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.47   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
17.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
17.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase long chain family member 4
VGNC:7793
740279
Macaque
acyl-CoA synthetase long chain family member 4
704908
Mouse
MGI:1354713
50790
Rat
RGD:69401
113976
Dog
acyl-CoA synthetase long chain family member 4
VGNC:37534
481018
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acyl-CoA synthetase long chain family member 4
Macaque
acyl-CoA synthetase long chain family member 4
Mouse
Rat
Dog
acyl-CoA synthetase long chain family member 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O60488-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (28)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Free fatty acids regulate insulin secretion
Reactome
Integration of energy metabolism
Reactome
Intracellular metabolism of fatty acids regulates insulin secretion
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Free fatty acids regulate insulin secretion
Integration of energy metabolism
Intracellular metabolism of fatty acids regulates insulin secretion
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (125)
1 – 10 of 125
TOR1AIP2
Tbio
Novelty: 0.08912351
p_int: 0.995056789
p_ni: 0.004943211
Data Source: BioPlex
GNAT2
Tbio
Novelty: 0.01683655
p_int: 0.95896454
p_ni: 0.04103546
Score: 0.229
Data Source: BioPlex,STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
p_int: 0.941798025
p_ni: 0.058201975
Score: 0.187
Data Source: BioPlex,STRINGDB
TBC1D22A
Tbio
Novelty: 0.46374046
p_int: 0.932643429
p_ni: 0.067356571
Score: 0.202
Data Source: BioPlex,STRINGDB
SLC22A2
Tchem
Family: Transporter
Novelty: 0.00439263
p_int: 0.890454443
p_ni: 0.109545557
Data Source: BioPlex
SLC6A15
Tchem
Family: Transporter
Novelty: 0.04011524
p_int: 0.884449562
p_ni: 0.115550438
Data Source: BioPlex
ORAI1
Tchem
Family: IC
Novelty: 0.00179685
p_int: 0.881155293
p_ni: 0.118844707
Data Source: BioPlex
SLC15A1
Tchem
Family: Transporter
Novelty: 0.00149723
p_int: 0.816319146
p_ni: 0.183680854
Data Source: BioPlex
EID3
Tdark
Novelty: 0.37412011
p_int: 0.814318645
p_ni: 0.185681355
Score: 0.201
Data Source: BioPlex,STRINGDB
SLC39A12
Tbio
Family: Transporter
Novelty: 0.09127395
p_int: 0.775807386
p_ni: 0.224192614
Data Source: BioPlex
Publication Statistics
PubMed Score  159.47

PubMed score by year
PubTator Score  63.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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