Tbio ACSL4 Long-chain-fatty-acid--CoA ligase 4

Protein Summary

Description

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates. The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the cognitive disability or Alport syndrome. Alternative splicing of this gene generates multiple transcript variants. [provided by RefSeq, Jan 2016]

Uniprot Accession IDs

• O60488
• D3DUY2
• O60848
• O60849
• Q5JWV8

Gene Name

• ACSL4

Ensembl ID

• ENST00000340800
• ENSP00000339787
• ENSG00000068366
• ENST00000348502
• ENSP00000262835
• ENST00000469796
• ENSP00000419171

Symbol

• ACS4
• FACL4
• LACS4
• ACS4
• FACL4
• LACS4
• MRX63
• MRX68

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
molecular function	0.91
microRNA	0.83
cellular component	0.78
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Ligase / Long-chain-fatty-acid--coa Ligase 4

DTO Classes

Protein / Enzyme / Ligase / Long-chain-fatty-acid--coa Ligase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.75   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 316   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 173.75   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 316   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (125)

Explore Interacting Targets

1 – 10 of 125

• See Interactions on String-DB

Q8NFQ8

Tbio

Novelty:  0.08912351

p_int:  0.995056789

p_ni:  0.004943211

Data Source:  BioPlex

GNAT2

Tbio

Novelty:  0.01683655

p_int:  0.95896454

p_ni:  0.04103546

Score:  0.229

Data Source:  BioPlex,STRINGDB

MME

Tclin

Family:  Enzyme

Novelty:  0.00019144

p_int:  0.941798025

p_ni:  0.058201975

Score:  0.187

Data Source:  BioPlex,STRINGDB

TBC1D22A

Tbio

Novelty:  0.46374046

p_int:  0.932643429

p_ni:  0.067356571

Score:  0.202

Data Source:  BioPlex,STRINGDB

SLC22A2

Tchem

Family:  Transporter

Novelty:  0.00439263

p_int:  0.890454443

p_ni:  0.109545557

Data Source:  BioPlex

SLC6A15

Tchem

Family:  Transporter

Novelty:  0.04011524

p_int:  0.884449562

p_ni:  0.115550438

Data Source:  BioPlex

ORAI1

Tchem

Family:  IC

Novelty:  0.00179685

p_int:  0.881155293

p_ni:  0.118844707

Data Source:  BioPlex

SLC15A1

Tchem

Family:  Transporter

Novelty:  0.00149723

p_int:  0.816319146

p_ni:  0.183680854

Data Source:  BioPlex

EID3

Tdark

Novelty:  0.37412011

p_int:  0.814318645

p_ni:  0.185681355

Score:  0.201

Data Source:  BioPlex,STRINGDB

SLC39A12

Tbio

Family:  Transporter

Novelty:  0.09127395

p_int:  0.775807386

p_ni:  0.224192614

Data Source:  BioPlex

Nearest Tclin Targets (1)

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Upstream (1)

1 – 1 of 1

PPARA

Tclin

Family:  Nuclear Receptor

KEGG Distance:  2

Common Pathways:  2

1: Adipocytokine signaling pathway

2: PPAR signaling pathway

Pathways (28)

Reactome (9)

KEGG (9)

PathwayCommons (4)

WikiPathways (6)

Fatty acid metabolism (R-HSA-8978868)

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Items per page:

5

1 – 5 of 9

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Fatty acid metabolism	176 targets	R-HSA-8978868
Reactome	Fatty acyl-CoA biosynthesis	37 targets	R-HSA-75105
Reactome	Free fatty acids regulate insulin secretion	11 targets	R-HSA-400451
Reactome	Integration of energy metabolism	111 targets	R-HSA-163685
Reactome	Intracellular metabolism of fatty acids regulates insulin secretion	3 targets	R-HSA-434313

Name	Explore in Pharos	Explore in Source
Fatty acid metabolism	176 targets	R-HSA-8978868
Fatty acyl-CoA biosynthesis	37 targets	R-HSA-75105
Free fatty acids regulate insulin secretion	11 targets	R-HSA-400451
Integration of energy metabolism	111 targets	R-HSA-163685
Intracellular metabolism of fatty acids regulates insulin secretion	3 targets	R-HSA-434313

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (26)

Functions (5)

Components (10)

Processes (11)

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10

1 – 5 of 5

GO Term	Evidence	Assigned by
arachidonate-CoA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
long-chain fatty acid-CoA ligase activity	Inferred from Direct Assay (IDA)	UniProtKB
very long-chain fatty acid-CoA ligase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
decanoate-CoA ligase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-EC

Disease Associations ()

No disease associations found

GWAS Traits (1)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1	1	1		42.3

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean platelet volume	EFO_0004584	1		42.3

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alport syndrome
Alternative splicing
ATP-binding
Complete proteome
Deafness
Disease mutation
Elliptocytosis
Endoplasmic reticulum
Fatty acid metabolism
Hereditary hemolytic anemia

GWAS Trait Find Similar Targets

No Header	No Header
mean platelet volume

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
limbs/digits/tail phenotype
mortality/aging
reproductive system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	acyl-CoA synthetase long chain family member 4	VGNC:7793	740279
Macaque	acyl-CoA synthetase long chain family member 4		704908
Mouse	acyl-CoA synthetase long-chain family member 4	MGI:1354713	50790
Rat	acyl-CoA synthetase long-chain family member 4	RGD:69401	113976
Dog	acyl-CoA synthetase long chain family member 4	VGNC:37534	481018

Species	Name	OMA	EggNOG	Inparanoid
Chimp	acyl-CoA synthetase long chain family member 4
Macaque	acyl-CoA synthetase long chain family member 4
Mouse	acyl-CoA synthetase long-chain family member 4
Rat	acyl-CoA synthetase long-chain family member 4
Dog	acyl-CoA synthetase long chain family member 4

Publication Statistics

PubMed Score 173.75

PubMed score by year

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PubTator Score 63.80

PubTator score by year

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Related Publications

Text Mined References (55)

GeneRif Annotations (37)

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PMID	Year	Title